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Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition.
Fogal V, Michopoulos F, Jarnuczak AF, Hamza GM, Harlfinger S, Davey P, Hulme H, Atkinson SJ, Gabrowski P, Cheung T, Grondine M, Hoover C, Rose J, Bray C, Foster AJ, Askin S, Majumder MM, Fitzpatrick P, Miele E, Macdonald R, Keun HC, Coen M. Fogal V, et al. Among authors: jarnuczak af. Arch Toxicol. 2024 Aug;98(8):2589-2603. doi: 10.1007/s00204-024-03771-w. Epub 2024 May 17. Arch Toxicol. 2024. PMID: 38755480 Free PMC article.
Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.
Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R. Saitoski K, et al. Among authors: jarnuczak af. J Biol Chem. 2022 Jul;298(7):102096. doi: 10.1016/j.jbc.2022.102096. Epub 2022 Jun 2. J Biol Chem. 2022. PMID: 35660019 Free PMC article.
An integrated landscape of protein expression in human cancer.
Jarnuczak AF, Najgebauer H, Barzine M, Kundu DJ, Ghavidel F, Perez-Riverol Y, Papatheodorou I, Brazma A, Vizcaíno JA. Jarnuczak AF, et al. Sci Data. 2021 Apr 23;8(1):115. doi: 10.1038/s41597-021-00890-2. Sci Data. 2021. PMID: 33893311 Free PMC article.
Using Deep Learning to Extrapolate Protein Expression Measurements.
Barzine MP, Freivalds K, Wright JC, Opmanis M, Rituma D, Ghavidel FZ, Jarnuczak AF, Celms E, Čerāns K, Jonassen I, Lace L, Vizcaíno JA, Choudhary JS, Brazma A, Viksna J. Barzine MP, et al. Among authors: jarnuczak af. Proteomics. 2020 Nov;20(21-22):e2000009. doi: 10.1002/pmic.202000009. Epub 2020 Oct 16. Proteomics. 2020. PMID: 32937025 Free PMC article.
The functional landscape of the human phosphoproteome.
Ochoa D, Jarnuczak AF, Viéitez C, Gehre M, Soucheray M, Mateus A, Kleefeldt AA, Hill A, Garcia-Alonso L, Stein F, Krogan NJ, Savitski MM, Swaney DL, Vizcaíno JA, Noh KM, Beltrao P. Ochoa D, et al. Among authors: jarnuczak af. Nat Biotechnol. 2020 Mar;38(3):365-373. doi: 10.1038/s41587-019-0344-3. Epub 2019 Dec 9. Nat Biotechnol. 2020. PMID: 31819260 Free PMC article.
The ProteomeXchange consortium in 2020: enabling 'big data' approaches in proteomics.
Deutsch EW, Bandeira N, Sharma V, Perez-Riverol Y, Carver JJ, Kundu DJ, García-Seisdedos D, Jarnuczak AF, Hewapathirana S, Pullman BS, Wertz J, Sun Z, Kawano S, Okuda S, Watanabe Y, Hermjakob H, MacLean B, MacCoss MJ, Zhu Y, Ishihama Y, Vizcaíno JA. Deutsch EW, et al. Among authors: jarnuczak af. Nucleic Acids Res. 2020 Jan 8;48(D1):D1145-D1152. doi: 10.1093/nar/gkz984. Nucleic Acids Res. 2020. PMID: 31686107 Free PMC article.
Expression Atlas update: from tissues to single cells.
Papatheodorou I, Moreno P, Manning J, Fuentes AM, George N, Fexova S, Fonseca NA, Füllgrabe A, Green M, Huang N, Huerta L, Iqbal H, Jianu M, Mohammed S, Zhao L, Jarnuczak AF, Jupp S, Marioni J, Meyer K, Petryszak R, Prada Medina CA, Talavera-López C, Teichmann S, Vizcaino JA, Brazma A. Papatheodorou I, et al. Among authors: jarnuczak af. Nucleic Acids Res. 2020 Jan 8;48(D1):D77-D83. doi: 10.1093/nar/gkz947. Nucleic Acids Res. 2020. PMID: 31665515 Free PMC article.
Quantifying the impact of public omics data.
Perez-Riverol Y, Zorin A, Dass G, Vu MT, Xu P, Glont M, Vizcaíno JA, Jarnuczak AF, Petryszak R, Ping P, Hermjakob H. Perez-Riverol Y, et al. Among authors: jarnuczak af. Nat Commun. 2019 Aug 5;10(1):3512. doi: 10.1038/s41467-019-11461-w. Nat Commun. 2019. PMID: 31383865 Free PMC article.
18 results