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Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling.
Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP. Villarreal MM, et al. Among authors: mendoza v. Biochemistry. 2016 Dec 13;55(49):6880-6896. doi: 10.1021/acs.biochem.6b00566. Epub 2016 Dec 2. Biochemistry. 2016. PMID: 27951653 Free PMC article.
Betaglycan has two independent domains required for high affinity TGF-beta binding: proteolytic cleavage separates the domains and inactivates the neutralizing activity of the soluble receptor.
Mendoza V, Vilchis-Landeros MM, Mendoza-Hernández G, Huang T, Villarreal MM, Hinck AP, López-Casillas F, Montiel JL. Mendoza V, et al. Among authors: mendoza hernandez g. Biochemistry. 2009 Dec 15;48(49):11755-65. doi: 10.1021/bi901528w. Biochemistry. 2009. PMID: 19842711 Free PMC article.
Soluble betaglycan reduces renal damage progression in db/db mice.
Juárez P, Vilchis-Landeros MM, Ponce-Coria J, Mendoza V, Hernández-Pando R, Bobadilla NA, López-Casillas F. Juárez P, et al. Among authors: mendoza v. Am J Physiol Renal Physiol. 2007 Jan;292(1):F321-9. doi: 10.1152/ajprenal.00264.2006. Epub 2006 Sep 5. Am J Physiol Renal Physiol. 2007. PMID: 16954341 Free article.
180 results