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Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology.
Gazula H, Tregidgo HFJ, Billot B, Balbastre Y, William-Ramirez J, Herisse R, Deden-Binder LJ, Casamitjana A, Melief EJ, Latimer CS, Kilgore MD, Montine M, Robinson E, Blackburn E, Marshall MS, Connors TR, Oakley DH, Frosch MP, Young SI, Van Leemput K, Dalca AV, FIschl B, Mac Donald CL, Keene CD, Hyman BT, Iglesias JE. Gazula H, et al. Among authors: keene cd. bioRxiv [Preprint]. 2024 Jan 30:2023.06.08.544050. doi: 10.1101/2023.06.08.544050. bioRxiv. 2024. Update in: Elife. 2024 Jun 19;12:RP91398. doi: 10.7554/eLife.91398 PMID: 37333251 Free PMC article. Updated. Preprint.
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ,… See abstract for full author list ➔ Rajabli F, et al. Among authors: keene cd. medRxiv [Preprint]. 2023 Jul 8:2023.07.06.23292311. doi: 10.1101/2023.07.06.23292311. medRxiv. 2023. PMID: 37461624 Free PMC article. Preprint.
Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation.
Braun M, Simon MJ, Jang J, Sanderson K, Swierz J, Sevao M, Pincus AB, Schaser AJ, Elliott JE, Lim MM, Unni VK, Schindler AG, Keene CD, Latimer CS, Iliff J. Braun M, et al. Among authors: keene cd. bioRxiv [Preprint]. 2024 Aug 19:2024.08.14.607971. doi: 10.1101/2024.08.14.607971. bioRxiv. 2024. PMID: 39229234 Free PMC article. Preprint.
Amyloid-β predominant Alzheimer's disease neuropathologic change.
Kovacs GG, Katsumata Y, Wu X, Aung KZ, Fardo DW, Forrest SL; Alzheimer's Disease Genetics Consortium; Nelson PT. Kovacs GG, et al. Brain. 2024 Oct 17:awae325. doi: 10.1093/brain/awae325. Online ahead of print. Brain. 2024. PMID: 39417691
B-BIND: Biophysical Bayesian Inference for Neurodegenerative Dynamics.
Agrawal A, Rachleff VM, Travaglini KJ, Mukherjee S, Crane PK, Hawrylycz M, Keene CD, Lein E, Mena GE, Gabitto MI. Agrawal A, et al. Among authors: keene cd. bioRxiv [Preprint]. 2024 Jul 31:2024.06.10.597236. doi: 10.1101/2024.06.10.597236. bioRxiv. 2024. PMID: 38915664 Free PMC article. Preprint.
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology.
Chemparathy A, Guen YL, Chen S, Lee EG, Leong L, Gorzynski J, Xu G, Belloy M, Kasireddy N, Tauber AP, Williams K, Stewart I, Wingo T, Lah J, Jayadev S, Hales C, Peskind E, Child DD, Keene CD, Cong L, Ashley E, Yu CE, Greicius MD. Chemparathy A, et al. Among authors: keene cd. medRxiv [Preprint]. 2023 Jul 24:2023.07.20.23292771. doi: 10.1101/2023.07.20.23292771. medRxiv. 2023. Update in: Neuron. 2024 Apr 3;112(7):1110-1116.e5. doi: 10.1016/j.neuron.2024.01.008 PMID: 37547016 Free PMC article. Updated. Preprint.
327 results