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The state of the art in secondary pharmacology and its impact on the safety of new medicines.
Brennan RJ, Jenkinson S, Brown A, Delaunois A, Dumotier B, Pannirselvam M, Rao M, Ribeiro LR, Schmidt F, Sibony A, Timsit Y, Sales VT, Armstrong D, Lagrutta A, Mittlestadt SW, Naven R, Peri R, Roberts S, Vergis JM, Valentin JP. Brennan RJ, et al. Among authors: lagrutta a. Nat Rev Drug Discov. 2024 Jul;23(7):525-545. doi: 10.1038/s41573-024-00942-3. Epub 2024 May 21. Nat Rev Drug Discov. 2024. PMID: 38773351 Review.
Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines.
Brennan RJ, Jenkinson S, Brown A, Delaunois A, Dumotier B, Pannirselvam M, Rao M, Ribeiro LR, Schmidt F, Sibony A, Timsit Y, Sales VT, Armstrong D, Lagrutta A, Mittlestadt SW, Naven R, Peri R, Roberts S, Vergis JM, Valentin JP. Brennan RJ, et al. Among authors: lagrutta a. Nat Rev Drug Discov. 2024 Jul;23(7):563. doi: 10.1038/s41573-024-00993-6. Nat Rev Drug Discov. 2024. PMID: 38886593 No abstract available.
An overview of drug-induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety.
Chaudhary KW, Clancy CE, Yang PC, Pierson JB, Goldin AL, Koerner JE, Wisialowski TA, Valentin JP, Imredy JP, Lagrutta A, Authier S, Kleiman R, Sager PT, Hoffmann P, Pugsley MK. Chaudhary KW, et al. Among authors: lagrutta a. Clin Transl Sci. 2024 Dec;17(12):e70098. doi: 10.1111/cts.70098. Clin Transl Sci. 2024. PMID: 39660576 Free PMC article. Review.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Vargas HM, Rolf MG, Wisialowski TA, Achanzar W, Bahinski A, Bass A, Benson CT, Chaudhary KW, Couvreur N, Dota C, Engwall MJ, Michael Foley C, Gallacher D, Greiter-Wilke A, Guillon JM, Guth B, Himmel HM, Hegele-Hartung C, Ito M, Jenkinson S, Chiba K, Lagrutta A, Levesque P, Martel E, Okai Y, Peri R, Pointon A, Qu Y, Teisman A, Traebert M, Yoshinaga T, Gintant GA, Leishman DJ, Valentin JP. Vargas HM, et al. Among authors: lagrutta a. Clin Pharmacol Ther. 2021 Feb;109(2):310-318. doi: 10.1002/cpt.2029. Epub 2020 Sep 24. Clin Pharmacol Ther. 2021. PMID: 32866317 Free PMC article. Review.
64 results