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Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis.
He X, Tolosa MF, Zhang T, Goru SK, Ulloa Severino L, Misra PS, McEvoy CM, Caldwell L, Szeto SG, Gao F, Chen X, Atin C, Ki V, Vukosa N, Hu C, Zhang J, Yip C, Krizova A, Wrana JL, Yuen DA. He X, et al. Among authors: yuen da. JCI Insight. 2022 Feb 22;7(4):e146243. doi: 10.1172/jci.insight.146243. JCI Insight. 2022. PMID: 35191398 Free PMC article.
NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling.
Zhang T, He X, Caldwell L, Goru SK, Ulloa Severino L, Tolosa MF, Misra PS, McEvoy CM, Christova T, Liu Y, Atin C, Zhang J, Hu C, Vukosa N, Chen X, Krizova A, Kirpalani A, Gregorieff A, Ni R, Chan K, Gill MK, Attisano L, Wrana JL, Yuen DA. Zhang T, et al. Among authors: yuen da. Sci Transl Med. 2022 Mar 23;14(637):eaaz4028. doi: 10.1126/scitranslmed.aaz4028. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320001
YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis.
Szeto SG, Narimatsu M, Lu M, He X, Sidiqi AM, Tolosa MF, Chan L, De Freitas K, Bialik JF, Majumder S, Boo S, Hinz B, Dan Q, Advani A, John R, Wrana JL, Kapus A, Yuen DA. Szeto SG, et al. Among authors: yuen da. J Am Soc Nephrol. 2016 Oct;27(10):3117-3128. doi: 10.1681/ASN.2015050499. Epub 2016 Mar 9. J Am Soc Nephrol. 2016. PMID: 26961347 Free PMC article.
A new, easily generated mouse model of diabetic kidney fibrosis.
He X, Zhang T, Tolosa M, Goru SK, Chen X, Misra PS, Robinson LA, Yuen DA. He X, et al. Among authors: yuen da. Sci Rep. 2019 Aug 29;9(1):12549. doi: 10.1038/s41598-019-49012-4. Sci Rep. 2019. PMID: 31467329 Free PMC article.
eNOS deficiency predisposes podocytes to injury in diabetes.
Yuen DA, Stead BE, Zhang Y, White KE, Kabir MG, Thai K, Advani SL, Connelly KA, Takano T, Zhu L, Cox AJ, Kelly DJ, Gibson IW, Takahashi T, Harris RC, Advani A. Yuen DA, et al. J Am Soc Nephrol. 2012 Nov;23(11):1810-23. doi: 10.1681/ASN.2011121170. Epub 2012 Sep 20. J Am Soc Nephrol. 2012. PMID: 22997257 Free PMC article.
92 results