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Reversible male contraception by targeted inhibition of serine/threonine kinase 33.
Ku AF, Sharma KL, Ta HM, Sutton CM, Bohren KM, Wang Y, Chamakuri S, Chen R, Hakenjos JM, Jimmidi R, Kent K, Li F, Li JY, Ma L, Madasu C, Palaniappan M, Palmer SS, Qin X, Robers MB, Sankaran B, Tan Z, Vasquez YM, Wang J, Wilkinson J, Yu Z, Ye Q, Young DW, Teng M, Kim C, Matzuk MM. Ku AF, et al. Among authors: teng m. Science. 2024 May 24;384(6698):885-890. doi: 10.1126/science.adl2688. Epub 2024 May 23. Science. 2024. PMID: 38781365
Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections.
Modukuri RK, Yu Z, Tan Z, Ta HM, Ucisik MN, Jin Z, Anglin JL, Sharma KL, Nyshadham P, Li F, Riehle K, Faver JC, Duong K, Nagarajan S, Simmons N, Palmer SS, Teng M, Young DW, Yi JS, Kim C, Matzuk MM. Modukuri RK, et al. Among authors: teng m. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2122506119. doi: 10.1073/pnas.2122506119. Epub 2022 May 27. Proc Natl Acad Sci U S A. 2022. PMID: 35622893 Free PMC article.
On-demand modular assembly for expedited PROTAC development.
Mukherjee A, Kadam VD, Miao Q, Zhang W, MacKenzie KR, Tan Z, Teng M. Mukherjee A, et al. Among authors: teng m. Expert Opin Drug Discov. 2024 Jul;19(7):769-772. doi: 10.1080/17460441.2024.2364637. Epub 2024 Jun 6. Expert Opin Drug Discov. 2024. PMID: 38842359 No abstract available.
The rise of degrader drugs.
Teng M, Gray NS. Teng M, et al. Cell Chem Biol. 2023 Aug 17;30(8):864-878. doi: 10.1016/j.chembiol.2023.06.020. Epub 2023 Jul 25. Cell Chem Biol. 2023. PMID: 37494935 Free article. Review.
Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues.
Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS. Hassan MM, et al. Among authors: teng m. bioRxiv [Preprint]. 2023 Oct 10:2023.10.07.561308. doi: 10.1101/2023.10.07.561308. bioRxiv. 2023. Update in: Eur J Med Chem. 2024 Dec 5;279:116904. doi: 10.1016/j.ejmech.2024.116904 PMID: 37873358 Free PMC article. Updated. Preprint.
Template-assisted covalent modification underlies activity of covalent molecular glues.
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Rutter JC, Lumpkin RJ, Sandoval B, Jin CY, Schmoker AM, Ficarro SB, Cheong H, Metivier RJ, Wang MY, Xu S, Byun WS, Groendyke BJ, You I, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Sperling HT, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL. Li YD, et al. Among authors: teng m. Nat Chem Biol. 2024 Dec;20(12):1640-1649. doi: 10.1038/s41589-024-01668-4. Epub 2024 Jul 29. Nat Chem Biol. 2024. PMID: 39075252 Free PMC article.
Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS. Hassan MM, et al. Among authors: teng m. Eur J Med Chem. 2024 Dec 5;279:116904. doi: 10.1016/j.ejmech.2024.116904. Epub 2024 Sep 24. Eur J Med Chem. 2024. PMID: 39341093 Free article.
1,512 results