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Page 1
Structure-based discovery of CFTR potentiators and inhibitors.
Liu F, Kaplan AL, Levring J, Einsiedel J, Tiedt S, Distler K, Omattage NS, Kondratov IS, Moroz YS, Pietz HL, Irwin JJ, Gmeiner P, Shoichet BK, Chen J. Liu F, et al. Among authors: levring j. Cell. 2024 Jul 11;187(14):3712-3725.e34. doi: 10.1016/j.cell.2024.04.046. Epub 2024 May 28. Cell. 2024. PMID: 38810646 Free PMC article.
Structural basis for CFTR inhibition by CFTRinh-172.
Young PG, Levring J, Fiedorczuk K, Blanchard SC, Chen J. Young PG, et al. Among authors: levring j. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2316675121. doi: 10.1073/pnas.2316675121. Epub 2024 Feb 29. Proc Natl Acad Sci U S A. 2024. PMID: 38422021 Free PMC article.
Structural identification of a selectivity filter in CFTR.
Levring J, Chen J. Levring J, et al. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2316673121. doi: 10.1073/pnas.2316673121. Epub 2024 Feb 21. Proc Natl Acad Sci U S A. 2024. PMID: 38381791 Free PMC article.
Structure-based discovery of CFTR potentiators and inhibitors.
Liu F, Kaplan AL, Levring J, Einsiedel J, Tiedt S, Distler K, Omattage NS, Kondratov IS, Moroz YS, Pietz HL, Irwin JJ, Gmeiner P, Shoichet BK, Chen J. Liu F, et al. Among authors: levring j. bioRxiv [Preprint]. 2024 Mar 11:2023.09.09.557002. doi: 10.1101/2023.09.09.557002. bioRxiv. 2024. Update in: Cell. 2024 Jul 11;187(14):3712-3725.e34. doi: 10.1016/j.cell.2024.04.046 PMID: 37745391 Free PMC article. Updated. Preprint.
Force-induced conformational changes in PIEZO1.
Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S. Lin YC, et al. Among authors: levring j. Nature. 2019 Sep;573(7773):230-234. doi: 10.1038/s41586-019-1499-2. Epub 2019 Aug 21. Nature. 2019. PMID: 31435018 Free PMC article.
Structural identification of a hotspot on CFTR for potentiation.
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J. Liu F, et al. Among authors: levring j. Science. 2019 Jun 21;364(6446):1184-1188. doi: 10.1126/science.aaw7611. Science. 2019. PMID: 31221859 Free PMC article.