Saghatelian A - Search Results

1

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.

Yan S, Santoro A, Niphakis MJ, Pinto AM, Jacobs CL, Ahmad R, Suciu RM, Fonslow BR, Herbst-Graham RA, Ngo N, Henry CL, Herbst DM, Saghatelian A, Kahn BB, Rosen ED. Yan S, et al. Among authors: saghatelian a. Nat Commun. 2024 May 30;15(1):4605. doi: 10.1038/s41467-024-48220-5. Nat Commun. 2024. PMID: 38816388 Free PMC article.

2

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.

Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Miraldi ER, et al. Among authors: saghatelian a. Integr Biol (Camb). 2013 Jul 24;5(7):940-63. doi: 10.1039/c3ib40013a. Epub 2013 May 20. Integr Biol (Camb). 2013. PMID: 23685806 Free PMC article.

3

Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Yore MM, et al. Among authors: saghatelian a. Cell. 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035. Cell. 2014. PMID: 25303528 Free PMC article.

4

Data-driven synthesis of proteolysis-resistant peptide hormones.

Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Prothiwa M, et al. Among authors: saghatelian a. J Am Chem Soc. 2014 Dec 24;136(51):17710-3. doi: 10.1021/ja5065735. Epub 2014 Dec 12. J Am Chem Soc. 2014. PMID: 25496053

5

A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids.

Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. Zhang T, et al. Among authors: saghatelian a. Nat Protoc. 2016 Apr;11(4):747-63. doi: 10.1038/nprot.2016.040. Epub 2016 Mar 17. Nat Protoc. 2016. PMID: 26985573 Free PMC article.

6

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.

Parsons WH, Kolar MJ, Kamat SS, Cognetta AB 3rd, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. Parsons WH, et al. Among authors: saghatelian a. Nat Chem Biol. 2016 May;12(5):367-372. doi: 10.1038/nchembio.2051. Epub 2016 Mar 28. Nat Chem Biol. 2016. PMID: 27018888 Free PMC article.

7

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects.

Moraes-Vieira PM, Saghatelian A, Kahn BB. Moraes-Vieira PM, et al. Among authors: saghatelian a. Diabetes. 2016 Jul;65(7):1808-15. doi: 10.2337/db16-0221. Epub 2016 Jun 10. Diabetes. 2016. PMID: 27288004 Free PMC article. Review.

8

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.

Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Kolar MJ, et al. Among authors: saghatelian a. Biochemistry. 2016 Aug 23;55(33):4636-41. doi: 10.1021/acs.biochem.6b00565. Epub 2016 Aug 10. Biochemistry. 2016. PMID: 27509211 Free PMC article.

9

Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses.

Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. Lee J, et al. Among authors: saghatelian a. J Biol Chem. 2016 Oct 14;291(42):22207-22217. doi: 10.1074/jbc.M115.703835. Epub 2016 Aug 29. J Biol Chem. 2016. PMID: 27573241 Free PMC article.

10

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.

Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. Grünberg JR, et al. Among authors: saghatelian a. Sci Rep. 2017 Feb 27;7:43515. doi: 10.1038/srep43515. Sci Rep. 2017. PMID: 28240264 Free PMC article.

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