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Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: channappanavar r. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free article.
Differential TLR-ERK1/2 activity promotes viral ssRNA and dsRNA mimic-induced dysregulated immunity in macrophages.
Shrestha R, Johnson P, Ghimire R, Whitley C, Channappanavar R. Shrestha R, et al. Among authors: channappanavar r. bioRxiv [Preprint]. 2024 May 25:2024.05.24.595760. doi: 10.1101/2024.05.24.595760. bioRxiv. 2024. Update in: Pathogens. 2024 Nov 23;13(12):1033. doi: 10.3390/pathogens13121033 PMID: 38826464 Free PMC article. Updated. Preprint.
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: channappanavar r. bioRxiv [Preprint]. 2024 Jul 12:2024.01.03.574082. doi: 10.1101/2024.01.03.574082. bioRxiv. 2024. Update in: J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24 PMID: 38260573 Free PMC article. Updated. Preprint.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice.
Alhammad YM, Parthasarathy S, Ghimire R, Kerr CM, O'Connor JJ, Pfannenstiel JJ, Chanda D, Miller CA, Baumlin N, Salathe M, Unckless RL, Zuñiga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. Among authors: channappanavar r. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120. Epub 2023 Aug 22. Proc Natl Acad Sci U S A. 2023. PMID: 37607224 Free PMC article.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
Alhammad YM, Parthasarathy S, Ghimire R, O'Connor JJ, Kerr CM, Pfannenstiel JJ, Chanda D, Miller CA, Unckless RL, Zuniga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. Among authors: channappanavar r. bioRxiv [Preprint]. 2023 Apr 6:2023.04.06.535927. doi: 10.1101/2023.04.06.535927. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120 PMID: 37066301 Free PMC article. Updated. Preprint.
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