Lai PK - Search Results

1

DeepSP: Deep learning-based spatial properties to predict monoclonal antibody stability.

Kalejaye L, Wu IE, Terry T, Lai PK. Kalejaye L, et al. Among authors: lai pk. Comput Struct Biotechnol J. 2024 May 18;23:2220-2229. doi: 10.1016/j.csbj.2024.05.029. eCollection 2024 Dec. Comput Struct Biotechnol J. 2024. PMID: 38827232 Free PMC article.

2

DeepSCM: An efficient convolutional neural network surrogate model for the screening of therapeutic antibody viscosity.

Lai PK. Lai PK. Comput Struct Biotechnol J. 2022 Apr 29;20:2143-2152. doi: 10.1016/j.csbj.2022.04.035. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35832619 Free PMC article.

3

Rapid discovery of Transglutaminase 2 inhibitors for celiac disease with boosting ensemble machine learning.

Wichka I, Lai PK. Wichka I, et al. Among authors: lai pk. Comput Struct Biotechnol J. 2024 Oct 16;23:3669-3679. doi: 10.1016/j.csbj.2024.10.019. eCollection 2024 Dec. Comput Struct Biotechnol J. 2024. PMID: 39498152 Free PMC article.

4

Machine Learning Models for Predicting Monoclonal Antibody Biophysical Properties from Molecular Dynamics Simulations and Deep Learning-Based Surface Descriptors.

Wu IE, Kalejaye L, Lai PK. Wu IE, et al. Among authors: lai pk. Mol Pharm. 2025 Jan 6;22(1):142-153. doi: 10.1021/acs.molpharmaceut.4c00804. Epub 2024 Nov 28. Mol Pharm. 2025. PMID: 39606945

5

Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters.

Lai PK, Swan JW, Trout BL. Lai PK, et al. MAbs. 2021 Jan-Dec;13(1):1907882. doi: 10.1080/19420862.2021.1907882. MAbs. 2021. PMID: 33834944 Free PMC article.

6

Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics.

Lai PK, Gallegos A, Mody N, Sathish HA, Trout BL. Lai PK, et al. MAbs. 2022 Jan-Dec;14(1):2026208. doi: 10.1080/19420862.2022.2026208. MAbs. 2022. PMID: 35075980 Free PMC article.

7

Machine Learning Feature Selection for Predicting High Concentration Therapeutic Antibody Aggregation.

Lai PK, Fernando A, Cloutier TK, Kingsbury JS, Gokarn Y, Halloran KT, Calero-Rubio C, Trout BL. Lai PK, et al. J Pharm Sci. 2021 Apr;110(4):1583-1591. doi: 10.1016/j.xphs.2020.12.014. Epub 2020 Dec 18. J Pharm Sci. 2021. PMID: 33346034

8

Machine Learning Applied to Determine the Molecular Descriptors Responsible for the Viscosity Behavior of Concentrated Therapeutic Antibodies.

Lai PK, Fernando A, Cloutier TK, Gokarn Y, Zhang J, Schwenger W, Chari R, Calero-Rubio C, Trout BL. Lai PK, et al. Mol Pharm. 2021 Mar 1;18(3):1167-1175. doi: 10.1021/acs.molpharmaceut.0c01073. Epub 2021 Jan 15. Mol Pharm. 2021. PMID: 33450157

9

Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions.

Lai PK, Ghag G, Yu Y, Juan V, Fayadat-Dilman L, Trout BL. Lai PK, et al. MAbs. 2021 Jan-Dec;13(1):1991256. doi: 10.1080/19420862.2021.1991256. MAbs. 2021. PMID: 34747330 Free PMC article.

10

Determination of Metabolic Fluxes by Deep Learning of Isotope Labeling Patterns.

Law RC, O'Keeffe S, Nurwono G, Ki R, Lakhani A, Lai PK, Park JO. Law RC, et al. Among authors: lai pk. bioRxiv [Preprint]. 2023 Nov 8:2023.11.06.565907. doi: 10.1101/2023.11.06.565907. bioRxiv. 2023. PMID: 37986781 Free PMC article. Preprint.

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