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Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor-ligand signaling complex.
Zeng J, Loi GWZ, Saipuljumri EN, Romero Durán MA, Silva-García O, Perez-Aguilar JM, Baizabal-Aguirre VM, Lo CH. Zeng J, et al. Among authors: saipuljumri en. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2308132121. doi: 10.1073/pnas.2308132121. Epub 2024 Mar 29. Proc Natl Acad Sci U S A. 2024. PMID: 38551841 Free PMC article.