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Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
Tharp KM, Kersten K, Maller O, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward MK, Berestjuk I, Ten Hoeve J, Samad B, Ironside AJ, di Magliano MP, Muir A, Geiger R, Combes AJ, Weaver VM. Tharp KM, et al. Among authors: geiger r. Nat Cancer. 2024 Jul;5(7):1045-1062. doi: 10.1038/s43018-024-00775-4. Epub 2024 Jun 3. Nat Cancer. 2024. PMID: 38831058
Metabolic modulation of tumours with engineered bacteria for immunotherapy.
Canale FP, Basso C, Antonini G, Perotti M, Li N, Sokolovska A, Neumann J, James MJ, Geiger S, Jin W, Theurillat JP, West KA, Leventhal DS, Lora JM, Sallusto F, Geiger R. Canale FP, et al. Among authors: geiger s, geiger r. Nature. 2021 Oct;598(7882):662-666. doi: 10.1038/s41586-021-04003-2. Epub 2021 Oct 6. Nature. 2021. PMID: 34616044
The roles of arginases and arginine in immunity.
Canè S, Geiger R, Bronte V. Canè S, et al. Among authors: geiger r. Nat Rev Immunol. 2024 Oct 17. doi: 10.1038/s41577-024-01098-2. Online ahead of print. Nat Rev Immunol. 2024. PMID: 39420221 Review.
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Tan J, Pieper K, Piccoli L, Abdi A, Perez MF, Geiger R, Tully CM, Jarrossay D, Maina Ndungu F, Wambua J, Bejon P, Fregni CS, Fernandez-Rodriguez B, Barbieri S, Bianchi S, Marsh K, Thathy V, Corti D, Sallusto F, Bull P, Lanzavecchia A. Tan J, et al. Among authors: geiger r. Nature. 2016 Jan 7;529(7584):105-109. doi: 10.1038/nature16450. Epub 2015 Dec 23. Nature. 2016. PMID: 26700814 Free PMC article.
Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy.
Martí i Líndez AA, Dunand-Sauthier I, Conti M, Gobet F, Núñez N, Hannich JT, Riezman H, Geiger R, Piersigilli A, Hahn K, Lemeille S, Becher B, De Smedt T, Hugues S, Reith W. Martí i Líndez AA, et al. Among authors: geiger r. JCI Insight. 2019 Nov 21;4(24):e132975. doi: 10.1172/jci.insight.132975. JCI Insight. 2019. PMID: 31751318 Free PMC article.
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
Chen Y, Xu K, Piccoli L, Foglierini M, Tan J, Jin W, Gorman J, Tsybovsky Y, Zhang B, Traore B, Silacci-Fregni C, Daubenberger C, Crompton PD, Geiger R, Sallusto F, Kwong PD, Lanzavecchia A. Chen Y, et al. Among authors: geiger r. Nature. 2021 Apr;592(7855):639-643. doi: 10.1038/s41586-021-03378-6. Epub 2021 Mar 31. Nature. 2021. PMID: 33790470 Free PMC article.
Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer.
Cacciatore A, Shinde D, Musumeci C, Sandrini G, Guarrera L, Albino D, Civenni G, Storelli E, Mosole S, Federici E, Fusina A, Iozzo M, Rinaldi A, Pecoraro M, Geiger R, Bolis M, Catapano CV, Carbone GM. Cacciatore A, et al. Among authors: geiger r. Nat Commun. 2024 Aug 6;15(1):6672. doi: 10.1038/s41467-024-50908-7. Nat Commun. 2024. PMID: 39107274 Free PMC article.
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
Bernasocchi T, El Tekle G, Bolis M, Mutti A, Vallerga A, Brandt LP, Spriano F, Svinkina T, Zoma M, Ceserani V, Rinaldi A, Janouskova H, Bossi D, Cavalli M, Mosole S, Geiger R, Dong Z, Yang CG, Albino D, Rinaldi A, Schraml P, Linder S, Carbone GM, Alimonti A, Bertoni F, Moch H, Carr SA, Zwart W, Kruithof-de Julio M, Rubin MA, Udeshi ND, Theurillat JP. Bernasocchi T, et al. Among authors: geiger r. Nat Commun. 2021 Feb 2;12(1):734. doi: 10.1038/s41467-020-20820-x. Nat Commun. 2021. PMID: 33531470 Free PMC article.
A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients.
Cassotta A, Mikol V, Bertrand T, Pouzieux S, Le Parc J, Ferrari P, Dumas J, Auer M, Deisenhammer F, Gastaldi M, Franciotta D, Silacci-Fregni C, Fernandez Rodriguez B, Giacchetto-Sasselli I, Foglierini M, Jarrossay D, Geiger R, Sallusto F, Lanzavecchia A, Piccoli L. Cassotta A, et al. Among authors: geiger r. Nat Med. 2019 Sep;25(9):1402-1407. doi: 10.1038/s41591-019-0568-2. Epub 2019 Sep 9. Nat Med. 2019. PMID: 31501610 Free PMC article.
383 results