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An engineered T7 RNA polymerase for efficient co-transcriptional capping with reduced dsRNA byproducts in mRNA synthesis.
Miller M, Alvizo O, Baskerville S, Chintala A, Chng C, Dassie J, Dorigatti J, Huisman G, Jenne S, Kadam S, Leatherbury N, Lutz S, Mayo M, Mukherjee A, Sero A, Sundseth S, Penfield J, Riggins J, Zhang X. Miller M, et al. Among authors: zhang x. Faraday Discuss. 2024 Sep 11;252(0):431-449. doi: 10.1039/d4fd00023d. Faraday Discuss. 2024. PMID: 38832894
Optimizing human α-galactosidase for treatment of Fabry disease.
Hallows WC, Skvorak K, Agard N, Kruse N, Zhang X, Zhu Y, Botham RC, Chng C, Shukla C, Lao J, Miller M, Sero A, Viduya J, Ismaili MHA, McCluskie K, Schiffmann R, Silverman AP, Shen JS, Huisman GW. Hallows WC, et al. Among authors: zhang x. Sci Rep. 2023 Mar 23;13(1):4748. doi: 10.1038/s41598-023-31777-4. Sci Rep. 2023. PMID: 36959353 Free PMC article.
A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins.
Fryszkowska A, An C, Alvizo O, Banerjee G, Canada KA, Cao Y, DeMong D, Devine PN, Duan D, Elgart DM, Farasat I, Gauthier DR, Guidry EN, Jia X, Kong J, Kruse N, Lexa KW, Makarov AA, Mann BF, Milczek EM, Mitchell V, Nazor J, Neri C, Orr RK, Orth P, Phillips EM, Riggins JN, Schafer WA, Silverman SM, Strulson CA, Subramanian N, Voladri R, Yang H, Yang J, Yi X, Zhang X, Zhong W. Fryszkowska A, et al. Among authors: zhang x. Science. 2022 Jun 17;376(6599):1321-1327. doi: 10.1126/science.abn2009. Epub 2022 Jun 16. Science. 2022. PMID: 35709255
Efficient, chemoenzymatic process for manufacture of the Boceprevir bicyclic [3.1.0]proline intermediate based on amine oxidase-catalyzed desymmetrization.
Li T, Liang J, Ambrogelly A, Brennan T, Gloor G, Huisman G, Lalonde J, Lekhal A, Mijts B, Muley S, Newman L, Tobin M, Wong G, Zaks A, Zhang X. Li T, et al. Among authors: zhang x. J Am Chem Soc. 2012 Apr 11;134(14):6467-72. doi: 10.1021/ja3010495. Epub 2012 Mar 28. J Am Chem Soc. 2012. PMID: 22409428
Baeyer-Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation.
Bong YK, Song S, Nazor J, Vogel M, Widegren M, Smith D, Collier SJ, Wilson R, Palanivel SM, Narayanaswamy K, Mijts B, Clay MD, Fong R, Colbeck J, Appaswami A, Muley S, Zhu J, Zhang X, Liang J, Entwistle D. Bong YK, et al. Among authors: zhang x. J Org Chem. 2018 Jul 20;83(14):7453-7458. doi: 10.1021/acs.joc.8b00468. Epub 2018 Jun 22. J Org Chem. 2018. PMID: 29932340
182,411 results
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