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mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA.
Chaves LCS, Orr-Burks N, Vanover D, Mosur VV, Hosking SR, Kumar E K P, Jeong H, Jung Y, Assumpção JAF, Peck HE, Nelson SL, Burke KN, Garrison MA, Arthur RA, Claussen H, Heaton NS, Lafontaine ER, Hogan RJ, Zurla C, Santangelo PJ. Chaves LCS, et al. Among authors: mosur vv. PLoS Pathog. 2024 Jul 5;20(7):e1012345. doi: 10.1371/journal.ppat.1012345. eCollection 2024 Jul. PLoS Pathog. 2024. PMID: 38968329 Free PMC article.
mRNA-encoded Cas13 can be used to treat dengue infections in mice.
Basu M, Zurla C, Auroni TT, Vanover D, Chaves LCS, Sadhwani H, Pathak H, Basu R, Beyersdorf JP, Amuda OO, Elsharkawy A, Mosur V, Arthur RA, Claussen H, Sasser LE, Wroe JA, Peck HE, Kumar M, Brinton MA, Santangelo PJ. Basu M, et al. Among authors: mosur v. Nat Microbiol. 2024 Aug;9(8):2160-2172. doi: 10.1038/s41564-024-01726-6. Epub 2024 Jun 5. Nat Microbiol. 2024. PMID: 38839984