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GPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via PKM2 activation.
Joladarashi D, Thej C, Mallaredy V, Magadum A, Cimini M, Gonzalez C, Truongcao M, Nigro JT, Sethi MK, Gibb AA, Benedict C, Koch WJ, Kishore R. Joladarashi D, et al. Among authors: thej c. iScience. 2024 Sep 24;27(10):111021. doi: 10.1016/j.isci.2024.111021. eCollection 2024 Oct 18. iScience. 2024. PMID: 39429777 Free PMC article.
Podoplanin Positive Cell-derived Extracellular Vesicles Contribute to Cardiac Amyloidosis After Myocardial Infarction.
Cimini M, Hansmann UHE, Gonzalez C, Chesney AD, Truongcao MM, Gao E, Wang T, Roy R, Forte E, Mallaredy V, Thej C, Magadum A, Joladarashi D, Benedict C, Koch WJ, Tükel Ç, Kishore R. Cimini M, et al. Among authors: thej c. bioRxiv [Preprint]. 2024 Jul 2:2024.06.28.601297. doi: 10.1101/2024.06.28.601297. bioRxiv. 2024. PMID: 39005419 Free PMC article. Preprint.
Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure.
Mallaredy V, Roy R, Cheng Z, Thej C, Benedict C, Truongcao M, Joladarashi D, Magadum A, Ibetti J, Cimini M, Gonzalez C, Garikipati VNS, Koch WJ, Kishore R. Mallaredy V, et al. Among authors: thej c. Circ Res. 2024 Jul 5;135(2):280-297. doi: 10.1161/CIRCRESAHA.123.324110. Epub 2024 Jun 7. Circ Res. 2024. PMID: 38847080 Free article.
Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition.
Huang G, Cheng Z, Hildebrand A, Wang C, Cimini M, Roy R, Lucchese AM, Benedict C, Mallaredy V, Magadum A, Joladarashi D, Thej C, Gonzalez C, Trungcao M, Garikipati VNS, Elrod JW, Koch WJ, Kishore R. Huang G, et al. Among authors: thej c. Theranostics. 2022 May 21;12(9):4415-4430. doi: 10.7150/thno.70821. eCollection 2022. Theranostics. 2022. PMID: 35673580 Free PMC article.
Phase IV postmarketing surveillance study shows continued efficacy and safety of Stempeucel in patients with critical limb ischemia due to Buerger's disease.
Gupta PK, Dutta S, Kala S, Nekkanti M, Desai SC, Mahapatra SS, Dhar A, Raju R, M R, Behera A, P S, Raviraja NS, Viswanathan P, Chandrashekar M, Thej C, K V P, Abraham J, Boggarapu H, Udaykumar K. Gupta PK, et al. Among authors: thej c. Stem Cells Transl Med. 2021 Dec;10(12):1602-1613. doi: 10.1002/sctm.21-0197. Epub 2021 Sep 13. Stem Cells Transl Med. 2021. PMID: 34519179 Free PMC article. Clinical Trial.
Human bone marrow-derived, pooled, allogeneic mesenchymal stromal cells manufactured from multiple donors at different times show comparable biological functions in vitro, and in vivo to repair limb ischemia.
Thej C, Balasubramanian S, Rengasamy M, Walvekar A, Swamynathan P, Raj SS, Shahani P, Siddikuzzaman, Kolkundkar U, Seetharam RN, Gupta PK, Majumdar AS. Thej C, et al. Stem Cell Res Ther. 2021 May 10;12(1):279. doi: 10.1186/s13287-021-02330-9. Stem Cell Res Ther. 2021. PMID: 33971964 Free PMC article.
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