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Developmental origin of oligodendrocytes determines their function in the adult brain.
Foerster S, Floriddia EM, van Bruggen D, Kukanja P, Hervé B, Cheng S, Kim E, Phillips BU, Heath CJ, Tripathi RB, Call C, Bartels T, Ridley K, Neumann B, López-Cruz L, Crawford AH, Lynch CJ, Serrano M, Saksida L, Rowitch DH, Möbius W, Nave KA, Rasband MN, Bergles DE, Kessaris N, Richardson WD, Bussey TJ, Zhao C, Castelo-Branco G, Franklin RJM. Foerster S, et al. Among authors: serrano m. Nat Neurosci. 2024 Aug;27(8):1545-1554. doi: 10.1038/s41593-024-01666-8. Epub 2024 Jun 7. Nat Neurosci. 2024. PMID: 38849524 Free PMC article.
Natural killer cells act as an extrinsic barrier for in vivo reprogramming.
Melendez E, Chondronasiou D, Mosteiro L, Martínez de Villarreal J, Fernández-Alfara M, Lynch CJ, Grimm D, Real FX, Alcamí J, Climent N, Pietrocola F, Serrano M. Melendez E, et al. Among authors: serrano m. Development. 2022 Apr 15;149(8):dev200361. doi: 10.1242/dev.200361. Epub 2022 Apr 22. Development. 2022. PMID: 35420133 Free PMC article.
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.
Lynch CJ, Bernad R, Martínez-Val A, Shahbazi MN, Nóbrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Ginés L, Alcazar N, Graña-Castro O, Gómez-Lopez G, Aksoy I, Muñoz-Martín M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Muñoz J, Zernicka-Goetz M, Serrano M. Lynch CJ, et al. Among authors: serrano m. Nat Cell Biol. 2020 Oct;22(10):1223-1238. doi: 10.1038/s41556-020-0573-1. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989249 Free article.
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells.
McHugh D, Sun B, Gutierrez-Muñoz C, Hernández-González F, Mellone M, Guiho R, Duran I, Pombo J, Pietrocola F, Birch J, Kallemeijn WW, Khadayate S, Dharmalingam G, Vernia S, Tate EW, Martínez-Barbera JP, Withers DJ, Thomas GJ, Serrano M, Gil J. McHugh D, et al. Among authors: serrano m. Nat Cell Biol. 2023 Dec;25(12):1804-1820. doi: 10.1038/s41556-023-01287-6. Epub 2023 Nov 27. Nat Cell Biol. 2023. PMID: 38012402 Free PMC article.
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2.
Chaib S, López-Domínguez JA, Lalinde-Gutiérrez M, Prats N, Marin I, Boix O, García-Garijo A, Meyer K, Muñoz MI, Aguilera M, Mateo L, Stephan-Otto Attolini C, Llanos S, Pérez-Ramos S, Escorihuela M, Al-Shahrour F, Cash TP, Tchkonia T, Kirkland JL, Abad M, Gros A, Arribas J, Serrano M. Chaib S, et al. Among authors: serrano m. Nat Cancer. 2024 Mar;5(3):448-462. doi: 10.1038/s43018-023-00712-x. Epub 2024 Jan 24. Nat Cancer. 2024. PMID: 38267628 Free PMC article.
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Wilkes MC, Siva K, Chen J, Varetti G, Youn MY, Chae H, Ek F, Olsson R, Lundbäck T, Dever DP, Nishimura T, Narla A, Glader B, Nakauchi H, Porteus MH, Repellin CE, Gazda HT, Lin S, Serrano M, Flygare J, Sakamoto KM. Wilkes MC, et al. Among authors: serrano m. Nat Commun. 2020 Jul 3;11(1):3344. doi: 10.1038/s41467-020-17100-z. Nat Commun. 2020. PMID: 32620751 Free PMC article.
2,014 results