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Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance.
Guenther KG, Lin X, Xu Z, Makriyannis A, Romero J, Hillard CJ, Mackie K, Hohmann AG. Guenther KG, et al. Among authors: mackie k. Biomed Pharmacother. 2024 Jul;176:116879. doi: 10.1016/j.biopha.2024.116879. Epub 2024 Jun 7. Biomed Pharmacother. 2024. PMID: 38850666 Free PMC article.
Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.
Carey LM, Xu Z, Rajic G, Makriyannis A, Romero J, Hillard C, Mackie K, Hohmann AG. Carey LM, et al. Among authors: mackie k. Pharmacol Res. 2023 Jan;187:106560. doi: 10.1016/j.phrs.2022.106560. Epub 2022 Nov 20. Pharmacol Res. 2023. PMID: 36417942 Free PMC article.
Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression.
Bernabeu A, Bara A, Murphy Green MN, Manduca A, Wager-Miller J, Borsoi M, Lassalle O, Pelissier-Alicot AL, Chavis P, Mackie K, Manzoni OJJ. Bernabeu A, et al. Among authors: mackie k. Cannabis Cannabinoid Res. 2023 Oct;8(5):749-767. doi: 10.1089/can.2022.0308. Epub 2023 Apr 4. Cannabis Cannabinoid Res. 2023. PMID: 37015060 Free PMC article.
Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors.
Kline T, Xu C, Kreitzer FR, Hurst DP, Eldeeb KM, Wager-Miller J, Olivas K, Hepburn SA, Huffman JW, Mackie K, Howlett AC, Reggio P, Stella N. Kline T, et al. Among authors: mackie k. Eur J Med Chem. 2023 Mar 5;249:115123. doi: 10.1016/j.ejmech.2023.115123. Epub 2023 Jan 26. Eur J Med Chem. 2023. PMID: 36708677 Free PMC article.
479 results