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Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI.
Lopatto EDB, Santiago-Borges JM, Sanick DA, Malladi SK, Azimzadeh PN, Timm MW, Fox IF, Schmitz AJ, Turner JS, Ahmed SS, Ortinau L, Gualberto NC, Pinkner JS, Dodson KW, Ellebedy AH, Kau AL, Hultgren SJ. Lopatto EDB, et al. Among authors: dodson kw. bioRxiv [Preprint]. 2024 Dec 11:2024.12.10.627638. doi: 10.1101/2024.12.10.627638. bioRxiv. 2024. PMID: 39713358 Free PMC article. Preprint.
Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection.
Young MG, Straub TJ, Worby CJ, Metsky HC, Gnirke A, Bronson RA, van Dijk LR, Desjardins CA, Matranga C, Qu J, Villicana JB, Azimzadeh P, Kau A, Dodson KW, Schreiber HL 4th, Manson AL, Hultgren SJ, Earl AM. Young MG, et al. Among authors: dodson kw. Nat Commun. 2024 Nov 2;15(1):9466. doi: 10.1038/s41467-024-53829-7. Nat Commun. 2024. PMID: 39487120 Free PMC article.
Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili.
Bitter RM, Zimmerman MI, Summers BT, Pinkner JS, Dodson KW, Hultgren SJ, Yuan P. Bitter RM, et al. Among authors: dodson kw. Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2410594121. doi: 10.1073/pnas.2410594121. Epub 2024 Sep 24. Proc Natl Acad Sci U S A. 2024. PMID: 39316053 Free PMC article.
Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis.
Lopatto EDB, Pinkner JS, Sanick DA, Potter RF, Liu LX, Bazán Villicaña J, Tamadonfar KO, Ye Y, Zimmerman MI, Gualberto NC, Dodson KW, Janetka JW, Hunstad DA, Hultgren SJ. Lopatto EDB, et al. Among authors: dodson kw. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2409655121. doi: 10.1073/pnas.2409655121. Epub 2024 Sep 17. Proc Natl Acad Sci U S A. 2024. PMID: 39288182 Free PMC article.
145 results