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Type-2 diabetes mellitus enhances Klebsiella pneumoniae pathogenesis.
Todd K, Gunter K, Bowen JM, Holmes CL, Tilston-Lunel NL, Vornhagen J. Todd K, et al. Among authors: holmes cl. bioRxiv [Preprint]. 2024 May 31:2024.05.31.596766. doi: 10.1101/2024.05.31.596766. bioRxiv. 2024. PMID: 38853822 Free PMC article. Preprint.
A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor.
Vornhagen J, Bassis CM, Ramakrishnan S, Hein R, Mason S, Bergman Y, Sunshine N, Fan Y, Holmes CL, Timp W, Schatz MC, Young VB, Simner PJ, Bachman MA. Vornhagen J, et al. Among authors: holmes cl. PLoS Pathog. 2021 Apr 30;17(4):e1009537. doi: 10.1371/journal.ppat.1009537. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33930099 Free PMC article.
Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection.
Vornhagen J, Roberts EK, Unverdorben L, Mason S, Patel A, Crawford R, Holmes CL, Sun Y, Teodorescu A, Snitkin ES, Zhao L, Simner PJ, Tamma PD, Rao K, Kaye KS, Bachman MA. Vornhagen J, et al. Among authors: holmes cl. Nat Commun. 2022 Aug 1;13(1):4459. doi: 10.1038/s41467-022-31990-1. Nat Commun. 2022. PMID: 35915063 Free PMC article.
Fitness factor genes conserved within the multi-species core genome of Gram-negative Enterobacterales species contribute to bacteremia pathogenesis.
Mobley HLT, Anderson MT, Moricz BS, Severin GB, Holmes CL, Ottosen EN, Eichler T, Gupta S, Paudel S, Sinha R, Mason S, Himpsl SD, Brown AN, Gaca M, Kiser CM, Clarke TH, Fouts DE, DiRita VJ, Bachman MA. Mobley HLT, et al. Among authors: holmes cl. PLoS Pathog. 2024 Aug 23;20(8):e1012495. doi: 10.1371/journal.ppat.1012495. eCollection 2024 Aug. PLoS Pathog. 2024. PMID: 39178317 Free PMC article.
69 results