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Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention and intervention.
Li Q, Song Q, Chen Z, Choi J, Moreno V, Ping J, Wen W, Li C, Shu X, Yan J, Shu XO, Cai Q, Long J, Huyghe JR, Pai R, Gruber SB, Casey G, Wang X, Toriola AT, Li L, Singh B, Lau KS, Zhou L, Wu C, Peters U, Zheng W, Long Q, Yin Z, Guo X. Li Q, et al. Among authors: pai r. medRxiv [Preprint]. 2024 May 31:2024.05.29.24308170. doi: 10.1101/2024.05.29.24308170. medRxiv. 2024. PMID: 38853880 Free PMC article. Preprint.
Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity.
Thomas M, Su YR, Rosenthal EA, Sakoda LC, Schmit SL, Timofeeva MN, Chen Z, Fernandez-Rozadilla C, Law PJ, Murphy N, Carreras-Torres R, Diez-Obrero V, van Duijnhoven FJ, Jiang S, Shin A, Wolk A, Phipps AI, Burnett-Hartman A, Gsur A, Chan AT, Zauber AG, Wu AH, Lindblom A, Um CY, Tangen CM, Gignoux C, Newton C, Haiman CA, Qu C, Bishop DT, Buchanan DD, Crosslin DR, Conti DV, Kim DH, Hauser E, White E, Siegel E, Schumacher FR, Rennert G, Giles GG, Hampel H, Brenner H, Oze I, Oh JH, Lee JK, Schneider JL, Chang-Claude J, Kim J, Huyghe JR, Zheng J, Hampe J, Greenson J, Hopper JL, Palmer JR, Visvanathan K, Matsuo K, Matsuda K, Jung KJ, Li L, Marchand LL, Vodickova L, Bujanda L, Gunter MJ, Matejcic M, Jenkins MA, Slattery ML, D'Amato M, Wang M, Hoffmeister M, Woods MO, Kim M, Song M, Iwasaki M, Du M, Udaltsova N, Sawada N, Vodicka P, Campbell PT, Newcomb PA, Cai Q, Pearlman R, Pai RK, Schoen RE, Steinfelder RS, Haile RW, Vandenputtelaar R, Prentice RL, Küry S, Castellví-Bel S, Tsugane S, Berndt SI, Lee SC, Brezina S, Weinstein SJ, Chanock SJ, Jee SH, Kweon SS, Vadaparampil S, Harrison TA, Yamaji T, Keku TO, Vymetalkova V, Arndt V, Jia WH, Shu XO, Lin Y, Ahn YO, Stadler ZK, Van Guelpe… See abstract for full author list ➔ Thomas M, et al. Among authors: pai rk. medRxiv [Preprint]. 2023 Jan 19:2023.01.19.23284737. doi: 10.1101/2023.01.19.23284737. medRxiv. 2023. Update in: Nat Commun. 2023 Oct 2;14(1):6147. doi: 10.1038/s41467-023-41819-0 PMID: 36789420 Free PMC article. Updated. Preprint.
Identifying metabolic features of colorectal cancer liability using Mendelian randomization.
Bull CJ, Hazelwood E, Bell JA, Tan VY, Constantinescu AE, Borges MC, Legge DN, Burrows K, Huyghe JR, Brenner H, Castellví-Bel S, Chan AT, Kweon SS, Marchand LL, Li L, Cheng I, Pai RK, Figueiredo JC, Murphy N, Gunter MJ, Timpson NJ, Vincent EE. Bull CJ, et al. Among authors: pai rk. medRxiv [Preprint]. 2023 Nov 9:2023.03.10.23287084. doi: 10.1101/2023.03.10.23287084. medRxiv. 2023. Update in: Elife. 2023 Dec 21;12:RP87894. doi: 10.7554/eLife.87894 PMID: 36945480 Free PMC article. Updated. Preprint.
Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival.
Georgeson P, Steinfelder RS, Harrison TA, Pope BJ, Zaidi SH, Qu C, Lin Y, Joo JE, Mahmood K, Clendenning M, Walker R, Aglago EK, Berndt SI, Brenner H, Campbell PT, Cao Y, Chan AT, Chang-Claude J, Dimou N, Doheny KF, Drew DA, Figueiredo JC, French AJ, Gallinger S, Giannakis M, Giles GG, Goode EL, Gruber SB, Gsur A, Gunter MJ, Harlid S, Hoffmeister M, Hsu L, Huang WY, Huyghe JR, Manson JE, Moreno V, Murphy N, Nassir R, Newton CC, Nowak JA, Obón-Santacana M, Ogino S, Pai RK, Papadimitrou N, Potter JD, Schoen RE, Song M, Sun W, Toland AE, Trinh QM, Tsilidis K, Ugai T, Um CY, Macrae FA, Rosty C, Hudson TJ, Winship IM, Phipps AI, Jenkins MA, Peters U, Buchanan DD. Georgeson P, et al. Among authors: pai rk. medRxiv [Preprint]. 2024 Jan 30:2023.03.10.23287127. doi: 10.1101/2023.03.10.23287127. medRxiv. 2024. PMID: 37090539 Free PMC article. Preprint.
Body mass index at birth and early life and colorectal cancer: A two-sample Mendelian randomization analysis in European and East Asian genetic similarity populations.
Papadimitriou N, Murphy N, Jenab M, Chen Z, Brenner H, Kweon SS, Le Marchand L, Moreno V, Platz EA, van Duijnhoven FJB, Cheng I, Pai RK, Phipps AI, Peters U, Zheng W, Hughes DJ. Papadimitriou N, et al. Among authors: pai rk. Pediatr Obes. 2025 Jan;20(1):e13186. doi: 10.1111/ijpo.13186. Epub 2024 Nov 25. Pediatr Obes. 2025. PMID: 39587448 Free PMC article.
Identifying metabolic features of colorectal cancer liability using Mendelian randomization.
Bull C, Hazelwood E, Bell JA, Tan V, Constantinescu AE, Borges C, Legge D, Burrows K, Huyghe JR, Brenner H, Castellvi-Bel S, Chan AT, Kweon SS, Le Marchand L, Li L, Cheng I, Pai RK, Figueiredo JC, Murphy N, Gunter MJ, Timpson NJ, Vincent EE. Bull C, et al. Among authors: pai rk. Elife. 2023 Dec 21;12:RP87894. doi: 10.7554/eLife.87894. Elife. 2023. PMID: 38127078 Free PMC article.
Causal relationships between risk of venous thromboembolism and 18 cancers: a bidirectional Mendelian randomisation analysis.
Cornish N, Haycock P, Brenner H, Figueiredo JC, Galesloot T, Grant RC; InterLymph consortium; INVENT-MVP consortium; Johansson M, Mariosa D, McKay J, Pai R, Pellatt AJ, Samadder NJ, Shi J, Thibord F, Trégouët DA, Voegele C, Thirlwell C, Mumford A, Langdon R. Cornish N, et al. Among authors: pai r. medRxiv [Preprint]. 2023 May 18:2023.05.16.23289792. doi: 10.1101/2023.05.16.23289792. medRxiv. 2023. Update in: Int J Epidemiol. 2024 Feb 1;53(1):dyad170. doi: 10.1093/ije/dyad170 PMID: 37292802 Free PMC article. Updated. Preprint.
Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis.
Rontogianni MO, Bouras E, Aglago EK, Freisling H, Murphy N, Cotterchio M, Hampe J, Lindblom A, Pai RK, Pharoah PDP, Phipps AI, van Duijnhoven FJB, Visvanathan K, van Guelpen B, Li CI, Brenner H, Pellatt AJ, Ogino S, Gunter MJ, Peters U, Christakoudi S, Tsilidis KK. Rontogianni MO, et al. Int J Obes (Lond). 2024 May;48(5):709-716. doi: 10.1038/s41366-024-01479-6. Epub 2024 Jan 31. Int J Obes (Lond). 2024. PMID: 38297030 Free PMC article.
Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients.
Wesselink E, Gauderman W, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Chan AT, Chang-Claude J, Cotterchoi M, Gunter MJ, Hoffmeister M, Joshi AD, Newton CC, Pai RK, Pellatt AJ, Phipps AI, Song M, Um CY, van Guelpen B, White E, Peters U, van Duijnhoven FJB. Wesselink E, et al. BJC Rep. 2024;2(1):63. doi: 10.1038/s44276-024-00077-3. Epub 2024 Sep 2. BJC Rep. 2024. PMID: 39233917 Free PMC article.
Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk.
Macinnis RJ, Jenkins MA, Milne RL, John EM, Daly MB, Andrulis IL, Colonna SV, Phillips KA; Kconfab Investigators; Le Marchand L, Newcomb PA, Phipps A, Schmit S, Macrae F, Buchanan D, Gallinger S, Pai RK, Samadder NJ, Giles GG, Southey MC, Hopper JL, Terry MB. Macinnis RJ, et al. Among authors: pai rk. JNCI Cancer Spectr. 2024 Dec 3:pkae121. doi: 10.1093/jncics/pkae121. Online ahead of print. JNCI Cancer Spectr. 2024. PMID: 39673461
1,126 results