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Repurposing the mucolytic agent ambroxol for treatment of sub-acute and chronic ischaemic stroke.
Patzwaldt K, Berezhnoy G, Ionescu T, Schramm L, Wang Y, Owczorz M, Calderón E, Poli S, Serna Higuita LM, Gonzalez-Menendez I, Quintanilla-Martinez L, Herfert K, Pichler B, Trautwein C, Castaneda-Vega S. Patzwaldt K, et al. Brain Commun. 2023 Mar 29;5(2):fcad099. doi: 10.1093/braincomms/fcad099. eCollection 2023. Brain Commun. 2023. PMID: 37065090 Free PMC article.
A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB.
Di Nanni A, Saw RS, Battisti UM, Bowden GD, Boeckermann A, Bjerregaard-Andersen K, Pichler BJ, Herfert K, Herth MM, Maurer A. Di Nanni A, et al. Among authors: pichler bj. ACS Omega. 2023 Aug 15;8(34):31450-31467. doi: 10.1021/acsomega.3c04292. eCollection 2023 Aug 29. ACS Omega. 2023. PMID: 37663501 Free PMC article.
Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells.
Wagner TR, Blaess S, Leske IB, Frecot DI, Gramlich M, Traenkle B, Kaiser PD, Seyfried D, Maier S, Rezza A, Sônego F, Thiam K, Pezzana S, Zeck A, Gouttefangeas C, Scholz AM, Nueske S, Maurer A, Kneilling M, Pichler BJ, Sonanini D, Rothbauer U. Wagner TR, et al. Among authors: pichler bj. Front Immunol. 2023 Dec 18;14:1264179. doi: 10.3389/fimmu.2023.1264179. eCollection 2023. Front Immunol. 2023. PMID: 38164132 Free PMC article.
Making the effect visible - OX40 targeting nanobodies for in vivo imaging of activated T cells.
Frecot DI, Blaess S, Wagner TR, Kaiser PD, Traenkle B, Fandrich M, Jakobi M, Scholz AM, Nueske S, Schneiderhan-Marra N, Gouttefangeas C, Kneilling M, Pichler BJ, Sonanini D, Rothbauer U. Frecot DI, et al. Among authors: pichler bj. Front Immunol. 2024 Oct 15;15:1480091. doi: 10.3389/fimmu.2024.1480091. eCollection 2024. Front Immunol. 2024. PMID: 39474429 Free PMC article.
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.
Gallage S, Ali A, Barragan Avila JE, Seymen N, Ramadori P, Joerke V, Zizmare L, Aicher D, Gopalsamy IK, Fong W, Kosla J, Focaccia E, Li X, Yousuf S, Sijmonsma T, Rahbari M, Kommoss KS, Billeter A, Prokosch S, Rothermel U, Mueller F, Hetzer J, Heide D, Schinkel B, Machauer T, Pichler B, Malek NP, Longerich T, Roth S, Rose AJ, Schwenck J, Trautwein C, Karimi MM, Heikenwalder M. Gallage S, et al. Cell Metab. 2024 Jun 4;36(6):1371-1393.e7. doi: 10.1016/j.cmet.2024.04.015. Epub 2024 May 7. Cell Metab. 2024. PMID: 38718791 Free article.
Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation.
Stegner D, Göb V, Krenzlin V, Beck S, Hemmen K, Schuhmann MK, Schörg BF, Hackenbroch C, May F, Burkard P, Pinnecker J, Zernecke A, Rosenberger P, Greinacher A, Pichler BJ, Heinze KG, Stoll G, Nieswandt B. Stegner D, et al. Among authors: pichler bj. Nat Cardiovasc Res. 2022 Feb;1(2):132-141. doi: 10.1038/s44161-021-00017-1. Epub 2022 Feb 10. Nat Cardiovasc Res. 2022. PMID: 39195988 Free PMC article.
236 results