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Page 1
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.
Mortensen DS, Fultz KE, Xu S, Xu W, Packard G, Khambatta G, Gamez JC, Leisten J, Zhao J, Apuy J, Ghoreishi K, Hickman M, Narla RK, Bissonette R, Richardson S, Peng SX, Perrin-Ninkovic S, Tran T, Shi T, Yang WQ, Tong Z, Cathers BE, Moghaddam MF, Canan SS, Worland P, Sankar S, Raymon HK. Mortensen DS, et al. Mol Cancer Ther. 2015 Jun;14(6):1295-305. doi: 10.1158/1535-7163.MCT-14-1052. Epub 2015 Apr 8. Mol Cancer Ther. 2015. PMID: 25855786
Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation.
Norris S, Ba X, Rhodes J, Huang D, Khambatta G, Buenviaje J, Nayak S, Meiring J, Reiss S, Xu S, Shi L, Whitefield B, Alexander M, Horn EJ, Correa M, Tehrani L, Hansen JD, Papa P, Mortensen DS. Norris S, et al. Among authors: mortensen ds. J Med Chem. 2023 Dec 14;66(23):16388-16409. doi: 10.1021/acs.jmedchem.3c01848. Epub 2023 Nov 22. J Med Chem. 2023. PMID: 37991844
Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001.
Nagy MA, Hilgraf R, Mortensen DS, Elsner J, Norris S, Tikhe J, Yoon W, Paisner D, Delgado M, Erdman P, Haelewyn J, Khambatta G, Xu L, Romanow WJ, Condroski K, Bahmanyar S, McCarrick M, Benish B, Blease K, LeBrun L, Moghaddam MF, Apuy J, Canan SS, Bennett BL, Satoh Y. Nagy MA, et al. Among authors: mortensen ds. J Med Chem. 2021 Dec 23;64(24):18193-18208. doi: 10.1021/acs.jmedchem.1c01716. Epub 2021 Dec 13. J Med Chem. 2021. PMID: 34894681
Correction to "Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation".
Norris S, Ba X, Rhodes J, Huang D, Khambatta G, Buenviaje J, Nayak S, Meiring J, Reiss S, Xu S, Shi L, Whitefield B, Alexander M, Horn EJ, Correa M, Tehrani L, Hansen JD, Papa P, Mortensen DS, Brazeau JF. Norris S, et al. Among authors: mortensen ds. J Med Chem. 2024 Aug 22;67(16):14692. doi: 10.1021/acs.jmedchem.4c01356. Epub 2024 Aug 13. J Med Chem. 2024. PMID: 39137243 No abstract available.
Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis.
Tummalapalli SR, Bhat R, Chojnowski A, Prorok M, Kreiss T, Goldberg R, Canan S, Hawryluk N, Mortensen D, Khetani V, Zeldis J, Siekierka JJ, Rotella DP. Tummalapalli SR, et al. ACS Med Chem Lett. 2018 Feb 9;9(3):210-214. doi: 10.1021/acsmedchemlett.7b00477. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541362 Free PMC article.
Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005.
Papa P, Whitefield B, Mortensen DS, Cashion D, Huang D, Torres E, Parnes J, Sapienza J, Hansen J, Correa M, Delgado M, Harris R, Hegde S, Norris S, Bahmanyar S, Plantevin-Krenitsky V, Liu Z, Leftheris K, Kulkarni A, Bennett B, Hur EM, Ringheim G, Khambatta G, Chan H, Muir J, Blease K, Burnett K, LeBrun L, Morrison L, Celeridad M, Khattri R, Cathers BE. Papa P, et al. Among authors: mortensen ds. J Med Chem. 2021 Aug 26;64(16):11886-11903. doi: 10.1021/acs.jmedchem.1c00388. Epub 2021 Aug 6. J Med Chem. 2021. PMID: 34355886
Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase.
Mortensen DS, Sapienza J, Lee BG, Perrin-Ninkovic SM, Harris R, Shevlin G, Parnes JS, Whitefield B, Hickman M, Khambatta G, Bisonette RR, Peng S, Gamez JC, Leisten J, Narla RK, Fultz KE, Sankar S. Mortensen DS, et al. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1588-91. doi: 10.1016/j.bmcl.2013.01.110. Epub 2013 Jan 30. Bioorg Med Chem Lett. 2013. PMID: 23414803
21 results