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Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria.
Bakker AT, Kotsogianni I, Avalos M, Punt JM, Liu B, Piermarini D, Gagestein B, Slingerland CJ, Zhang L, Willemse JJ, Ghimire LB, van den Berg RJHBN, Janssen APA, Ottenhoff THM, van Boeckel CAA, van Wezel GP, Ghilarov D, Martin NI, van der Stelt M. Bakker AT, et al. Among authors: zhang l. Nat Chem. 2024 Sep;16(9):1462-1472. doi: 10.1038/s41557-024-01516-x. Epub 2024 Jun 19. Nat Chem. 2024. PMID: 38898213 Free PMC article.
Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D.
Arora P, Zhang L, Nehlmeier I, Kempf A, Graichen L, Kreitz E, Sidarovich A, Rocha C, Gärtner S, Winkler M, Schulz S, Jäck H-M, Hoffmann M, Pöhlmann S. Arora P, et al. Among authors: zhang l. J Virol. 2025 Jan 10:e0123024. doi: 10.1128/jvi.01230-24. Online ahead of print. J Virol. 2025. PMID: 39791910
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