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Page 1
The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency.
Sheridan M, Maqbool MA, Largeot A, Clayfield L, Xu J, Moncaut N, Sellers R, Whittle J, Paggetti J, Iqbal M, Aucagne R, Delva L, Baker SM, Lie-A-Ling M, Kouskoff V, Lacaud G. Sheridan M, et al. Among authors: largeot a. J Hematol Oncol. 2024 Oct 8;17(1):91. doi: 10.1186/s13045-024-01610-0. J Hematol Oncol. 2024. PMID: 39380002 Free PMC article.
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia.
Sauter C, Morin T, Guidez F, Simonet J, Fournier C, Row C, Masnikov D, Pernon B, Largeot A, Aznague A, Hérault Y, Sauvageau G, Maynadié M, Callanan M, Bastie JN, Aucagne R, Delva L. Sauter C, et al. Among authors: largeot a. Commun Biol. 2024 Jun 20;7(1):753. doi: 10.1038/s42003-024-06453-6. Commun Biol. 2024. PMID: 38902349 Free PMC article.
Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia.
Pagano G, Botana IF, Wierz M, Roessner PM, Ioannou N, Zhou X, Al-Hity G, Borne C, Gargiulo E, Gonder S, Qu B, Stamatopoulos B, Ramsay AG, Seiffert M, Largeot A, Moussay E, Paggetti J. Pagano G, et al. Among authors: largeot a. Haematologica. 2023 Nov 1;108(11):3011-3024. doi: 10.3324/haematol.2022.282474. Haematologica. 2023. PMID: 37345470 Free PMC article.
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL.
Largeot A, Klapp V, Viry E, Gonder S, Fernandez Botana I, Blomme A, Benzarti M, Pierson S, Duculty C, Marttila P, Wierz M, Gargiulo E, Pagano G, An N, El Hachem N, Perez Hernandez D, Chakraborty S, Ysebaert L, François JH, Cortez Clemente S, Berchem G, Efremov DG, Dittmar G, Szpakowska M, Chevigné A, Nazarov PV, Helleday T, Close P, Meiser J, Stamatopoulos B, Désaubry L, Paggetti J, Moussay E. Largeot A, et al. Blood. 2023 Jun 29;141(26):3166-3183. doi: 10.1182/blood.2022017839. Blood. 2023. PMID: 37084385 Free PMC article.
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses.
Gargiulo E, Viry E, Morande PE, Largeot A, Gonder S, Xian F, Ioannou N, Benzarti M, Kleine Borgmann FB, Mittelbronn M, Dittmar G, Nazarov PV, Meiser J, Stamatopoulos B, Ramsay AG, Moussay E, Paggetti J. Gargiulo E, et al. Among authors: largeot a. Blood Cancer Discov. 2023 Jan 6;4(1):54-77. doi: 10.1158/2643-3230.BCD-22-0029. Blood Cancer Discov. 2023. PMID: 36108149 Free PMC article.
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling.
Wurzer H, Filali L, Hoffmann C, Krecke M, Biolato AM, Mastio J, De Wilde S, François JH, Largeot A, Berchem G, Paggetti J, Moussay E, Thomas C. Wurzer H, et al. Among authors: largeot a. Front Immunol. 2021 May 24;12:619069. doi: 10.3389/fimmu.2021.619069. eCollection 2021. Front Immunol. 2021. PMID: 34108958 Free PMC article.
20 results