Manhart CM - Search Results

1

The Mlh1-Pms1 endonuclease uses ATP to preserve DNA discontinuities as strand discrimination signals to facilitate mismatch repair.

Piscitelli JM, Witte SJ, Sakinejad YS, Manhart CM. Piscitelli JM, et al. Among authors: manhart cm. bioRxiv [Preprint]. 2024 Jun 13:2024.06.13.598860. doi: 10.1101/2024.06.13.598860. bioRxiv. 2024. PMID: 38915520 Free PMC article. Preprint.

2

The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension.

Witte SJ, Rosa IM, Collingwood BW, Piscitelli JM, Manhart CM. Witte SJ, et al. Among authors: manhart cm. Nucleic Acids Res. 2023 Apr 11;51(6):2725-2739. doi: 10.1093/nar/gkad096. Nucleic Acids Res. 2023. PMID: 36840719 Free PMC article.

3

Action-At-A-Distance in DNA Mismatch Repair: Mechanistic Insights and Models for How DNA and Repair Proteins Facilitate Long-Range Communication.

Collingwood BW, Witte SJ, Manhart CM. Collingwood BW, et al. Among authors: manhart cm. Biomolecules. 2024 Nov 13;14(11):1442. doi: 10.3390/biom14111442. Biomolecules. 2024. PMID: 39595618 Free PMC article. Review.

4

Mlh1-Pms1 ATPase activity is regulated distinctly by self-generated nicks and strand discrimination signals in mismatch repair.

Piscitelli JM, Witte SJ, Sakinejad YS, Manhart CM. Piscitelli JM, et al. Among authors: manhart cm. Nucleic Acids Res. 2024 Dec 19:gkae1253. doi: 10.1093/nar/gkae1253. Online ahead of print. Nucleic Acids Res. 2024. PMID: 39704127

5

Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis.

Gioia M, Payero L, Salim S, Fajish V G, Farnaz AF, Pannafino G, Chen JJ, Ajith VP, Momoh S, Scotland M, Raghavan V, Manhart CM, Shinohara A, Nishant KT, Alani E. Gioia M, et al. Among authors: manhart cm. PLoS Biol. 2023 Apr 20;21(4):e3002085. doi: 10.1371/journal.pbio.3002085. eCollection 2023 Apr. PLoS Biol. 2023. PMID: 37079643 Free PMC article.

6

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex.

Kim Y, Furman CM, Manhart CM, Alani E, Finkelstein IJ. Kim Y, et al. Among authors: manhart cm. Nucleic Acids Res. 2019 Feb 28;47(4):1823-1835. doi: 10.1093/nar/gky1244. Nucleic Acids Res. 2019. PMID: 30541127 Free PMC article.

7

mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.

Al-Sweel N, Raghavan V, Dutta A, Ajith VP, Di Vietro L, Khondakar N, Manhart CM, Surtees JA, Nishant KT, Alani E. Al-Sweel N, et al. Among authors: manhart cm. PLoS Genet. 2017 Aug 21;13(8):e1006974. doi: 10.1371/journal.pgen.1006974. eCollection 2017 Aug. PLoS Genet. 2017. PMID: 28827832 Free PMC article.

8

DNA replication and mismatch repair safeguard against metabolic imbalances.

Manhart CM, Alani E. Manhart CM, et al. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5561-5563. doi: 10.1073/pnas.1705971114. Epub 2017 May 22. Proc Natl Acad Sci U S A. 2017. PMID: 28533419 Free PMC article. No abstract available.

9

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.

Manhart CM, Ni X, White MA, Ortega J, Surtees JA, Alani E. Manhart CM, et al. PLoS Biol. 2017 Apr 28;15(4):e2001164. doi: 10.1371/journal.pbio.2001164. eCollection 2017 Apr. PLoS Biol. 2017. PMID: 28453523 Free PMC article.

10

Roles for mismatch repair family proteins in promoting meiotic crossing over.

Manhart CM, Alani E. Manhart CM, et al. DNA Repair (Amst). 2016 Feb;38:84-93. doi: 10.1016/j.dnarep.2015.11.024. Epub 2015 Dec 2. DNA Repair (Amst). 2016. PMID: 26686657 Free PMC article. Review.

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