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Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells.
Song W, Beigneux AP, Winther AL, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. Song W, et al. Among authors: jung h, jung cj. J Clin Invest. 2022 Mar 1;132(5):e157500. doi: 10.1172/JCI157500. J Clin Invest. 2022. PMID: 35229724 Free PMC article.
Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures.
Song W, Yang Y, Heizer P, Tu Y, Weston TA, Kim JR, Munguia P, Jung H, Fong JL, Tran C, Ploug M, Beigneux AP, Young SG, Fong LG. Song W, et al. Among authors: jung h. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2219833120. doi: 10.1073/pnas.2219833120. Epub 2023 Feb 14. Proc Natl Acad Sci U S A. 2023. PMID: 36787365 Free PMC article.
Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen.
Yang Y, Beigneux AP, Song W, Nguyen LP, Jung H, Tu Y, Weston TA, Tran CM, Xie K, Yu RG, Tran AP, Miyashita K, Nakajima K, Murakami M, Chen YQ, Zhen EY, Kim JR, Kim PH, Birrane G, Tontonoz P, Ploug M, Konrad RJ, Fong LG, Young SG. Yang Y, et al. Among authors: jung h. J Clin Invest. 2023 Dec 1;133(23):e172600. doi: 10.1172/JCI172600. J Clin Invest. 2023. PMID: 37824203 Free PMC article.
The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.
Song W, Beigneux AP, Weston TA, Chen K, Yang Y, Nguyen LP, Guagliardo P, Jung H, Tran AP, Tu Y, Tran C, Birrane G, Miyashita K, Nakajima K, Murakami M, Tontonoz P, Jiang H, Ploug M, Fong LG, Young SG. Song W, et al. Among authors: jung h. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2313825120. doi: 10.1073/pnas.2313825120. Epub 2023 Oct 23. Proc Natl Acad Sci U S A. 2023. PMID: 37871217 Free PMC article.
Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity.
Chen YQ, Yang Y, Zhen EY, Beyer TP, Li H, Wen Y, Ehsani M, Jackson N, Xie K, Jung H, Scheithauer JL, Kumari A, Birrane G, Russell AM, Balasubramaniam D, Liao Z, Siegel RW, Qian Y, Ploug M, Young SG, Konrad RJ. Chen YQ, et al. Among authors: jung h. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2322332121. doi: 10.1073/pnas.2322332121. Epub 2024 Apr 16. Proc Natl Acad Sci U S A. 2024. PMID: 38625948 Free PMC article.
Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species.
Nguyen LP, Song W, Yang Y, Tran AP, Weston TA, Jung H, Tu Y, Kim PH, Kim JR, Xie K, Yu RG, Scheithauer J, Presnell AM, Ploug M, Birrane G, Arnold H, Koltowska K, Mäe MA, Betsholtz C, He L, Goodwin JL, Beigneux AP, Fong LG, Young SG. Nguyen LP, et al. Among authors: jung h. JCI Insight. 2024 Sep 17;9(20):e184940. doi: 10.1172/jci.insight.184940. JCI Insight. 2024. PMID: 39435661 Free PMC article.
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