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Page 1
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor.
Neumann EN, Bertozzi TM, Wu E, Serack F, Harvey JW, Brauer PP, Pirtle CP, Coffey A, Howard M, Kamath N, Lenz K, Guzman K, Raymond MH, Khalil AS, Deverman BE, Minikel EV, Vallabh SM, Weissman JS. Neumann EN, et al. Among authors: brauer pp. Science. 2024 Jun 28;384(6703):ado7082. doi: 10.1126/science.ado7082. Epub 2024 Jun 28. Science. 2024. PMID: 38935715
An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery.
Huang Q, Chan KY, Lou S, Keyes C, Wu J, Botticello-Romero NR, Zheng Q, Johnston J, Mills A, Brauer PP, Clouse G, Pacouret S, Harvey JW, Beddow T, Hurley JK, Tobey IG, Powell M, Chen AT, Barry AJ, Eid FE, Chan YA, Deverman BE. Huang Q, et al. Among authors: brauer pp. bioRxiv [Preprint]. 2023 Dec 22:2023.12.20.572615. doi: 10.1101/2023.12.20.572615. bioRxiv. 2023. Update in: Science. 2024 Jun 14;384(6701):1220-1227. doi: 10.1126/science.adm8386 PMID: 38187643 Free PMC article. Updated. Preprint.
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery.
Huang Q, Chan KY, Wu J, Botticello-Romero NR, Zheng Q, Lou S, Keyes C, Svanbergsson A, Johnston J, Mills A, Lin CY, Brauer PP, Clouse G, Pacouret S, Harvey JW, Beddow T, Hurley JK, Tobey IG, Powell M, Chen AT, Barry AJ, Eid FE, Chan YA, Deverman BE. Huang Q, et al. Among authors: brauer pp. Science. 2024 Jun 14;384(6701):1220-1227. doi: 10.1126/science.adm8386. Epub 2024 May 16. Science. 2024. PMID: 38753766
Systematic multi-trait AAV capsid engineering for efficient gene delivery.
Eid FE, Chen AT, Chan KY, Huang Q, Zheng Q, Tobey IG, Pacouret S, Brauer PP, Keyes C, Powell M, Johnston J, Zhao B, Lage K, Tarantal AF, Chan YA, Deverman BE. Eid FE, et al. Among authors: brauer pp. Nat Commun. 2024 Aug 4;15(1):6602. doi: 10.1038/s41467-024-50555-y. Nat Commun. 2024. PMID: 39097583 Free PMC article.
In vivo base editing extends lifespan of a humanized mouse model of prion disease.
An M, Davis JR, Levy JM, Serack FE, Harvey JW, Brauer PP, Pirtle CP, Berríos KN, Newby GA, Yeh WH, Kamath N, Mortberg M, Lian Y, Howard M, DeSouza-Lenz K, Guzman K, Thai A, Graffam S, Coffey AA, Frei J, Pierce SE, Safar JG, Deverman BE, Minikel EV, Vallabh SM, Liu DR. An M, et al. Among authors: brauer pp. Nat Med. 2025 Jan 14. doi: 10.1038/s41591-024-03466-w. Online ahead of print. Nat Med. 2025. PMID: 39810005
Conservation of a CD1 multigene family in the guinea pig.
Dascher CC, Hiromatsu K, Naylor JW, Brauer PP, Brown KA, Storey JR, Behar SM, Kawasaki ES, Porcelli SA, Brenner MB, LeClair KP. Dascher CC, et al. Among authors: brauer pp. J Immunol. 1999 Nov 15;163(10):5478-88. J Immunol. 1999. PMID: 10553074
A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments.
Chang HC, Bao Z, Yao Y, Tse AG, Goyarts EC, Madsen M, Kawasaki E, Brauer PP, Sacchettini JC, Nathenson SG, et al. Chang HC, et al. Among authors: brauer pp. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11408-12. doi: 10.1073/pnas.91.24.11408. Proc Natl Acad Sci U S A. 1994. PMID: 7972074 Free PMC article.