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Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor.
Neumann EN, Bertozzi TM, Wu E, Serack F, Harvey JW, Brauer PP, Pirtle CP, Coffey A, Howard M, Kamath N, Lenz K, Guzman K, Raymond MH, Khalil AS, Deverman BE, Minikel EV, Vallabh SM, Weissman JS. Neumann EN, et al. Among authors: khalil as. Science. 2024 Jun 28;384(6703):ado7082. doi: 10.1126/science.ado7082. Epub 2024 Jun 28. Science. 2024. PMID: 38935715
Barcoded microbial system for high-resolution object provenance.
Qian J, Lu ZX, Mancuso CP, Jhuang HY, Del Carmen Barajas-Ornelas R, Boswell SA, Ramírez-Guadiana FH, Jones V, Sonti A, Sedlack K, Artzi L, Jung G, Arammash M, Pettit ME, Melfi M, Lyon L, Owen SV, Baym M, Khalil AS, Silver PA, Rudner DZ, Springer M. Qian J, et al. Among authors: khalil as. Science. 2020 Jun 5;368(6495):1135-1140. doi: 10.1126/science.aba5584. Science. 2020. PMID: 32499444
Here to stay: Writing lasting epigenetic memories.
Moussa HF, Angstman JF, Khalil AS. Moussa HF, et al. Among authors: khalil as. Cell. 2021 Apr 29;184(9):2281-2283. doi: 10.1016/j.cell.2021.04.007. Cell. 2021. PMID: 33930295 Free article.
One cell, many fates.
Kunze C, Khalil AS. Kunze C, et al. Among authors: khalil as. Science. 2022 Jan 21;375(6578):262-263. doi: 10.1126/science.abn6548. Epub 2022 Jan 20. Science. 2022. PMID: 35050646
The sound of silence: Transgene silencing in mammalian cell engineering.
Cabrera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, Khalil AS, Wong WW, Collins JJ, Rosser SJ, Polizzi K, Elowitz MB, Fussenegger M, Hilton IB, Leonard JN, Bintu L, Galloway KE, Deans TL. Cabrera A, et al. Among authors: khalil as. Cell Syst. 2022 Dec 21;13(12):950-973. doi: 10.1016/j.cels.2022.11.005. Cell Syst. 2022. PMID: 36549273 Free PMC article. Review.
Chromatin regulation at the frontier of synthetic biology.
Keung AJ, Joung JK, Khalil AS, Collins JJ. Keung AJ, et al. Among authors: khalil as. Nat Rev Genet. 2015 Mar;16(3):159-71. doi: 10.1038/nrg3900. Epub 2015 Feb 10. Nat Rev Genet. 2015. PMID: 25668787 Free PMC article. Review.
The epigenome: the next substrate for engineering.
Park M, Keung AJ, Khalil AS. Park M, et al. Among authors: khalil as. Genome Biol. 2016 Aug 31;17(1):183. doi: 10.1186/s13059-016-1046-5. Genome Biol. 2016. PMID: 27582168 Free PMC article. Review.
121 results