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Page 1
Molecular glues as potential GPCR therapeutics.
Roth BL, Krumm BE. Roth BL, et al. Biochem Pharmacol. 2024 Oct;228:116402. doi: 10.1016/j.bcp.2024.116402. Epub 2024 Jun 28. Biochem Pharmacol. 2024. PMID: 38945274 Review.
High-affinity agonists reveal recognition motifs for the MRGPRD GPCR.
Wang C, Liu Y, Lanier M, Yeager A, Singh I, Gumpper RH, Krumm BE, DeLeon C, Zhang S, Boehm M, Pittner R, Baron A, Dvorak L, Bacon C, Shoichet BK, Martinborough E, Fay JF, Cao C, Roth BL. Wang C, et al. Among authors: roth bl. Cell Rep. 2024 Dec 24;43(12):114942. doi: 10.1016/j.celrep.2024.114942. Epub 2024 Nov 23. Cell Rep. 2024. PMID: 39580805 Free article.
Structure-guided design of a peripherally restricted chemogenetic system.
Kang HJ, Krumm BE, Tassou A, Geron M, DiBerto JF, Kapolka NJ, Gumpper RH, Sakamoto K, Dewran Kocak D, Olsen RHJ, Huang XP, Zhang S, Huang KL, Zaidi SA, Nguyen MT, Jo MJ, Katritch V, Fay JF, Scherrer G, Roth BL. Kang HJ, et al. Among authors: roth bl. Cell. 2024 Dec 26;187(26):7433-7449.e20. doi: 10.1016/j.cell.2024.11.001. Epub 2024 Dec 3. Cell. 2024. PMID: 39631393
Illuminating the understudied GPCR-ome.
Majumdar S, Chiu YT, Pickett JE, Roth BL. Majumdar S, et al. Among authors: roth bl. Drug Discov Today. 2024 Mar;29(3):103848. doi: 10.1016/j.drudis.2023.103848. Epub 2023 Dec 3. Drug Discov Today. 2024. PMID: 38052317 Review.
The structure, function, and pharmacology of MRGPRs.
Cao C, Roth BL. Cao C, et al. Among authors: roth bl. Trends Pharmacol Sci. 2023 Apr;44(4):237-251. doi: 10.1016/j.tips.2023.02.002. Epub 2023 Mar 2. Trends Pharmacol Sci. 2023. PMID: 36870785 Free PMC article. Review.
Psychedelics as Transformative Therapeutics.
Roth BL, Gumpper RH. Roth BL, et al. Am J Psychiatry. 2023 May 1;180(5):340-347. doi: 10.1176/appi.ajp.20230172. Am J Psychiatry. 2023. PMID: 37122272 Review.
546 results