Akey DL - Search Results

1

Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation.

McCullough TM, Choudhary V, Akey DL, Skiba MA, Bernard SM, Kittendorf JD, Schmidt JJ, Sherman DH, Smith JL. McCullough TM, et al. Among authors: akey dl. bioRxiv [Preprint]. 2024 Jun 20:2024.06.20.599880. doi: 10.1101/2024.06.20.599880. bioRxiv. 2024. PMID: 38948807 Free PMC article. Preprint.

2

Structural basis for macrolactonization by the pikromycin thioesterase.

Akey DL, Kittendorf JD, Giraldes JW, Fecik RA, Sherman DH, Smith JL. Akey DL, et al. Nat Chem Biol. 2006 Oct;2(10):537-42. doi: 10.1038/nchembio824. Epub 2006 Sep 10. Nat Chem Biol. 2006. PMID: 16969372

3

Structure of a modular polyketide synthase reducing region.

McCullough TM, Dhar A, Akey DL, Konwerski JR, Sherman DH, Smith JL. McCullough TM, et al. Among authors: akey dl. Structure. 2023 Sep 7;31(9):1109-1120.e3. doi: 10.1016/j.str.2023.05.019. Epub 2023 Jun 21. Structure. 2023. PMID: 37348494 Free PMC article.

4

Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels.

Giraldes JW, Akey DL, Kittendorf JD, Sherman DH, Smith JL, Fecik RA. Giraldes JW, et al. Among authors: akey dl. Nat Chem Biol. 2006 Oct;2(10):531-6. doi: 10.1038/nchembio822. Epub 2006 Sep 10. Nat Chem Biol. 2006. PMID: 16969373

5

Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.

Scaglione JB, Akey DL, Sullivan R, Kittendorf JD, Rath CM, Kim ES, Smith JL, Sherman DH. Scaglione JB, et al. Among authors: akey dl. Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5726-30. doi: 10.1002/anie.201000032. Angew Chem Int Ed Engl. 2010. PMID: 20623733 Free PMC article. No abstract available.

6

Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases.

Bernard SM, Akey DL, Tripathi A, Park SR, Konwerski JR, Anzai Y, Li S, Kato F, Sherman DH, Smith JL. Bernard SM, et al. Among authors: akey dl. ACS Chem Biol. 2015 May 15;10(5):1340-51. doi: 10.1021/cb5009348. Epub 2015 Feb 26. ACS Chem Biol. 2015. PMID: 25692963 Free PMC article.

7

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.

Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL. Akey DL, et al. Structure. 2010 Jan 13;18(1):94-105. doi: 10.1016/j.str.2009.10.018. Structure. 2010. PMID: 20152156 Free PMC article.

8

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.

Chemler JA, Buchholz TJ, Geders TW, Akey DL, Rath CM, Chlipala GE, Smith JL, Sherman DH. Chemler JA, et al. Among authors: akey dl. J Am Chem Soc. 2012 May 2;134(17):7359-66. doi: 10.1021/ja2112228. Epub 2012 Apr 23. J Am Chem Soc. 2012. PMID: 22480290 Free PMC article.

9

A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.

Akey DL, Li S, Konwerski JR, Confer LA, Bernard SM, Anzai Y, Kato F, Sherman DH, Smith JL. Akey DL, et al. J Mol Biol. 2011 Oct 21;413(2):438-50. doi: 10.1016/j.jmb.2011.08.040. Epub 2011 Aug 23. J Mol Biol. 2011. PMID: 21884704 Free PMC article.

10

Insights from the sea: structural biology of marine polyketide synthases.

Akey DL, Gehret JJ, Khare D, Smith JL. Akey DL, et al. Nat Prod Rep. 2012 Oct;29(10):1038-49. doi: 10.1039/c2np20016c. Epub 2012 Apr 13. Nat Prod Rep. 2012. PMID: 22498975 Free PMC article. Review.

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