König GM - Search Results

1

GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism.

Matthees ESF, Filor JC, Jaiswal N, Reichel M, Youssef N, D'Uonnolo G, Szpakowska M, Drube J, König GM, Kostenis E, Chevigné A, Godbole A, Hoffmann C. Matthees ESF, et al. Among authors: konig gm. Commun Biol. 2024 Jul 3;7(1):802. doi: 10.1038/s42003-024-06490-1. Commun Biol. 2024. PMID: 38956302 Free PMC article.

2

Oxytocin-Modulated Ion Channel Ensemble Controls Depolarization, Integration and Burst Firing in CA2 Pyramidal Neurons.

Liu JJ, Eyring KW, König GM, Kostenis E, Tsien RW. Liu JJ, et al. Among authors: konig gm. J Neurosci. 2022 Oct 12;42(41):7707-7720. doi: 10.1523/JNEUROSCI.0921-22.2022. Epub 2022 Sep 8. J Neurosci. 2022. PMID: 36414006 Free PMC article.

3

Author Correction: Selective optogenetic control of G_q signaling using human Neuropsin.

Wagdi A, Malan D, Sathyanarayanan U, Beauchamp JS, Vogt M, Zipf D, Beiert T, Mansuroglu B, Dusend V, Meininghaus M, Schneider L, Kalthof B, Wiegert JS, König GM, Kostenis E, Patejdl R, Sasse P, Bruegmann T. Wagdi A, et al. Among authors: konig gm. Nat Commun. 2023 Jan 4;14(1):58. doi: 10.1038/s41467-022-35612-8. Nat Commun. 2023. PMID: 36599836 Free PMC article. No abstract available.

4

Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets.

Lorza-Gil E, Kaiser G, Carlein C, Hoffmann MDA, König GM, Haug S, Prates Roma L, Rexen Ulven E, Ulven T, Kostenis E, Birkenfeld AL, Häring HU, Ullrich S, Gerst F. Lorza-Gil E, et al. Among authors: konig gm. Diabetologia. 2023 Aug;66(8):1501-1515. doi: 10.1007/s00125-023-05932-5. Epub 2023 May 23. Diabetologia. 2023. PMID: 37217659 Free PMC article.

5

The Bacterial G_q Signal Transduction Inhibitor FR900359 Impairs Soil-Associated Nematodes.

Hanke W, Alenfelder J, Liu J, Gutbrod P, Kehraus S, Crüsemann M, Dörmann P, Kostenis E, Scholz M, König GM. Hanke W, et al. Among authors: konig gm. J Chem Ecol. 2023 Oct;49(9-10):549-569. doi: 10.1007/s10886-023-01442-1. Epub 2023 Jul 15. J Chem Ecol. 2023. PMID: 37453001 Free PMC article.

6

A molecular mechanism to diversify Ca²⁺ signaling downstream of Gs protein-coupled receptors.

Brands J, Bravo S, Jürgenliemke L, Grätz L, Schihada H, Frechen F, Alenfelder J, Pfeil C, Ohse PG, Hiratsuka S, Kawakami K, Schmacke LC, Heycke N, Inoue A, König G, Pfeifer A, Wachten D, Schulte G, Steinmetzer T, Watts VJ, Gomeza J, Simon K, Kostenis E. Brands J, et al. Nat Commun. 2024 Sep 3;15(1):7684. doi: 10.1038/s41467-024-51991-6. Nat Commun. 2024. PMID: 39227390 Free PMC article.

7

Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension.

Seidinger A, Roberts R, Bai Y, Müller M, Pfeil E, Matthey M, Rieck S, Alenfelder J, König GM, Pfeifer A, Kostenis E, Klinke A, Fleischmann BK, Wenzel D. Seidinger A, et al. Among authors: konig gm. EMBO Mol Med. 2024 Aug;16(8):1930-1956. doi: 10.1038/s44321-024-00096-0. Epub 2024 Jul 8. EMBO Mol Med. 2024. PMID: 38977926 Free PMC article.

8

Structure-affinity and structure-residence time relationships of macrocyclic Gα_q protein inhibitors.

Voss JH, Crüsemann M, Bartling CRO, Kehraus S, Inoue A, König GM, Strømgaard K, Müller CE. Voss JH, et al. Among authors: konig gm. iScience. 2023 Mar 23;26(4):106492. doi: 10.1016/j.isci.2023.106492. eCollection 2023 Apr 21. iScience. 2023. PMID: 37091255 Free PMC article.

9

Biosynthesis of the corallorazines, a widespread class of antibiotic cyclic lipodipeptides.

Dreckmann TM, Fritz L, Kaiser CF, Bouhired SM, Wirtz DA, Rausch M, Müller A, Schneider T, König GM, Crüsemann M. Dreckmann TM, et al. Among authors: konig gm. RSC Chem Biol. 2024 Aug 16;5(10):970-80. doi: 10.1039/d4cb00157e. Online ahead of print. RSC Chem Biol. 2024. PMID: 39184525 Free PMC article.

10

Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy.

Bonifer C, Hanke W, Mühle J, Löhr F, Becker-Baldus J, Nagel J, Schertler GFX, Müller CE, König GM, Hilger D, Glaubitz C. Bonifer C, et al. Among authors: konig gm. Chem Sci. 2024 Jul 4;15(32):12939-12956. doi: 10.1039/d4sc01950d. eCollection 2024 Aug 14. Chem Sci. 2024. PMID: 39148790 Free PMC article.

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