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Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Baltgalvis KA, Lamb KN, Symons KT, Wu CC, Hoffman MA, Snead AN, Song X, Glaza T, Kikuchi S, Green JC, Rogness DC, Lam B, Rodriguez-Aguirre ME, Woody DR, Eissler CL, Rodiles S, Negron SM, Bernard SM, Tran E, Pollock J, Tabatabaei A, Contreras V, Williams HN, Pastuszka MK, Sigler JJ, Pettazzoni P, Rudolph MG, Classen M, Brugger D, Claiborne C, Plancher JM, Cuartas I, Seoane J, Burgess LE, Abraham RT, Weinstein DS, Simon GM, Patricelli MP, Kinsella TM. Baltgalvis KA, et al. Among authors: simon gm. Nature. 2024 Jul;631(8021):E12. doi: 10.1038/s41586-024-07595-7. Nature. 2024. PMID: 38961306 No abstract available.
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Baltgalvis KA, Lamb KN, Symons KT, Wu CC, Hoffman MA, Snead AN, Song X, Glaza T, Kikuchi S, Green JC, Rogness DC, Lam B, Rodriguez-Aguirre ME, Woody DR, Eissler CL, Rodiles S, Negron SM, Bernard SM, Tran E, Pollock J, Tabatabaei A, Contreras V, Williams HN, Pastuszka MK, Sigler JJ, Pettazzoni P, Rudolph MG, Classen M, Brugger D, Claiborne C, Plancher JM, Cuartas I, Seoane J, Burgess LE, Abraham RT, Weinstein DS, Simon GM, Patricelli MP, Kinsella TM. Baltgalvis KA, et al. Among authors: simon gm. Nature. 2024 May;629(8011):435-442. doi: 10.1038/s41586-024-07318-y. Epub 2024 Apr 24. Nature. 2024. PMID: 38658751
Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2.
Klebba JE, Roy N, Bernard SM, Grabow S, Hoffman MA, Miao H, Tamiya J, Wang J, Berry C, Esparza-Oros A, Lin R, Liu Y, Pariollaud M, Parker H, Mochalkin I, Rana S, Snead AN, Walton EJ, Wyrick TE, Aitichson E, Bedke K, Brannon JC, Chick JM, Hee K, Horning BD, Ismail M, Lamb KN, Lin W, Metzger J, Pastuszka MK, Pollock J, Sigler JJ, Tomaschko M, Tran E, Kinsella TM, Molina-Arcas M, Simon GM, Weinstein DS, Downward J, Patricelli MP. Klebba JE, et al. Among authors: simon gm. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001. doi: 10.1101/2024.12.17.629001. bioRxiv. 2024. PMID: 39763752 Free PMC article. Preprint.
Assigning functionality to cysteines by base editing of cancer dependency genes.
Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF. Li H, et al. Among authors: simon gm. Nat Chem Biol. 2023 Nov;19(11):1320-1330. doi: 10.1038/s41589-023-01428-w. Epub 2023 Oct 2. Nat Chem Biol. 2023. PMID: 37783940 Free PMC article.
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. Lazear MR, et al. Among authors: simon gm. Mol Cell. 2023 May 18;83(10):1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026. Epub 2023 Apr 20. Mol Cell. 2023. PMID: 37084731 Free PMC article.
Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Kavanagh ME, Horning BD, Khattri R, Roy N, Lu JP, Whitby LR, Ye E, Brannon JC, Parker A, Chick JM, Eissler CL, Wong AJ, Rodriguez JL, Rodiles S, Masuda K, Teijaro JR, Simon GM, Patricelli MP, Cravatt BF. Kavanagh ME, et al. Among authors: simon gm. Nat Chem Biol. 2022 Nov;18(11):1288. doi: 10.1038/s41589-022-01181-6. Nat Chem Biol. 2022. PMID: 36180594 No abstract available.
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Kavanagh ME, Horning BD, Khattri R, Roy N, Lu JP, Whitby LR, Ye E, Brannon JC, Parker A, Chick JM, Eissler CL, Wong AJ, Rodriguez JL, Rodiles S, Masuda K, Teijaro JR, Simon GM, Patricelli MP, Cravatt BF. Kavanagh ME, et al. Among authors: simon gm. Nat Chem Biol. 2022 Dec;18(12):1388-1398. doi: 10.1038/s41589-022-01098-0. Epub 2022 Sep 12. Nat Chem Biol. 2022. PMID: 36097295 Free PMC article.
DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.
Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, Kinsella TM, Simon GM, Baltgalvis KA, Cravatt BF. Zhang X, et al. Among authors: simon gm. J Am Chem Soc. 2021 Apr 7;143(13):5141-5149. doi: 10.1021/jacs.1c00990. Epub 2021 Mar 30. J Am Chem Soc. 2021. PMID: 33783207 Free PMC article.
52 results