Nielsen JC - Search Results

1

Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties.

Nielsen JC, Hjo Rringgaard C, Nygaard MMR, Wester A, Elster L, Porsgaard T, Mikkelsen RB, Rasmussen S, Madsen AN, Schlein M, Vrang N, Rigbolt K, Dalbo Ge LS. Nielsen JC, et al. J Med Chem. 2024 Jul 25;67(14):11814-11826. doi: 10.1021/acs.jmedchem.4c00417. Epub 2024 Jul 8. J Med Chem. 2024. PMID: 38977267 Free PMC article.

2

A convergent solid-phase synthesis of actinomycin analogues--towards implementation of double-combinatorial chemistry.

Tong G, Nielsen J. Tong G, et al. Bioorg Med Chem. 1996 May;4(5):693-8. doi: 10.1016/0968-0896(96)00065-x. Bioorg Med Chem. 1996. PMID: 8804535

3

Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers.

Olsen JA, Severinsen R, Rasmussen TB, Hentzer M, Givskov M, Nielsen J. Olsen JA, et al. Bioorg Med Chem Lett. 2002 Feb 11;12(3):325-8. doi: 10.1016/s0960-894x(01)00756-9. Bioorg Med Chem Lett. 2002. PMID: 11814788

4

Engineering yeast to produce plant-derived anti-obesity agent.

Nielsen J. Nielsen J. Nat Chem. 2023 Sep;15(9):1204-1205. doi: 10.1038/s41557-023-01292-0. Nat Chem. 2023. PMID: 37640851 No abstract available.

5

Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism.

Zhang J, Petersen SD, Radivojevic T, Ramirez A, Pérez-Manríquez A, Abeliuk E, Sánchez BJ, Costello Z, Chen Y, Fero MJ, Martin HG, Nielsen J, Keasling JD, Jensen MK. Zhang J, et al. Nat Commun. 2020 Sep 25;11(1):4880. doi: 10.1038/s41467-020-17910-1. Nat Commun. 2020. PMID: 32978375 Free PMC article.

6

Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community.

Blasche S, Kim Y, Mars RAT, Machado D, Maansson M, Kafkia E, Milanese A, Zeller G, Teusink B, Nielsen J, Benes V, Neves R, Sauer U, Patil KR. Blasche S, et al. Nat Microbiol. 2021 Feb;6(2):196-208. doi: 10.1038/s41564-020-00816-5. Epub 2021 Jan 4. Nat Microbiol. 2021. PMID: 33398099 Free PMC article.

7

Machine learning-based investigation of the cancer protein secretory pathway.

Saghaleyni R, Sheikh Muhammad A, Bangalore P, Nielsen J, Robinson JL. Saghaleyni R, et al. PLoS Comput Biol. 2021 Apr 5;17(4):e1008898. doi: 10.1371/journal.pcbi.1008898. eCollection 2021 Apr. PLoS Comput Biol. 2021. PMID: 33819271 Free PMC article.

8

Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.

Bratulic S, Limeta A, Maccari F, Galeotti F, Volpi N, Levin M, Nielsen J, Gatto F. Bratulic S, et al. J Biol Chem. 2022 Feb;298(2):101575. doi: 10.1016/j.jbc.2022.101575. Epub 2022 Jan 8. J Biol Chem. 2022. PMID: 35007531 Free PMC article.

9

Hap4 is not essential for activation of respiration at low specific growth rates in Saccharomyces cerevisiae.

Raghevendran V, Patil KR, Olsson L, Nielsen J. Raghevendran V, et al. J Biol Chem. 2006 May 5;281(18):12308-14. doi: 10.1074/jbc.M512972200. Epub 2006 Mar 7. J Biol Chem. 2006. PMID: 16522629 Free article.

10

Transcriptional, proteomic, and metabolic responses to lithium in galactose-grown yeast cells.

Bro C, Regenberg B, Lagniel G, Labarre J, Montero-Lomelí M, Nielsen J. Bro C, et al. J Biol Chem. 2003 Aug 22;278(34):32141-9. doi: 10.1074/jbc.M304478200. Epub 2003 Jun 5. J Biol Chem. 2003. PMID: 12791685 Free article.

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