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Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer.
Murphy B, Miyamoto T, Manning BS, Mirji G, Ugolini A, Kannan T, Hamada K, Zhu YP, Claiborne DT, Huang L, Zhang R, Nefedova Y, Kossenkov A, Veglia F, Shinde R, Zhang N. Murphy B, et al. Among authors: kossenkov a. bioRxiv [Preprint]. 2024 Jun 29:2024.06.25.600597. doi: 10.1101/2024.06.25.600597. bioRxiv. 2024. Update in: J Exp Med. 2024 Dec 2;221(12):e20231967. doi: 10.1084/jem.20231967 PMID: 38979222 Free PMC article. Updated. Preprint.
Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression.
Tcyganov EN, Kwak T, Yang X, Poli ANR, Hart C, Bhuniya A, Cassel J, Kossenkov A, Auslander N, Lu L, Sharma P, Mendoza MGC, Zhigarev D, Cadungog MG, Jean S, Chatterjee-Paer S, Weiner D, Donthireddy L, Bristow B, Zhang R, Tyurin VA, Tyurina YY, Bayir H, Kagan VE, Salvino JM, Montaner LJ. Tcyganov EN, et al. Among authors: kossenkov a. bioRxiv [Preprint]. 2024 May 14:2024.05.10.593562. doi: 10.1101/2024.05.10.593562. bioRxiv. 2024. PMID: 38798466 Free PMC article. Preprint.
Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection.
Giron LB, Liu Q, Adeniji OS, Yin X, Kannan T, Ding J, Lu DY, Langan S, Zhang J, Azevedo JLLC, Li SH, Shalygin S, Azadi P, Hanna DB, Ofotokun I, Lazar J, Fischl MA, Haberlen S, Macatangay B, Adimora AA, Jamieson BD, Rinaldo C, Merenstein D, Roan NR, Kutsch O, Gange S, Wolinsky S, Witt M, Post WS, Kossenkov A, Landay A, Frank I, Tien PC, Gross R, Brown TT, Abdel-Mohsen M. Giron LB, et al. Among authors: kossenkov a. bioRxiv [Preprint]. 2023 Dec 31:2023.08.09.551369. doi: 10.1101/2023.08.09.551369. bioRxiv. 2023. Update in: Nat Commun. 2024 Apr 10;15(1):3035. doi: 10.1038/s41467-024-47279-4 PMID: 37609144 Free PMC article. Updated. Preprint.
Age-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesis.
Alicea GM, Portuallo ME, Patel P, Fane ME, Carey AE, Speicher D, Tang HY, Kossenkov AV, Rebecca VW, Wirtz DG, Weeraratna AT. Alicea GM, et al. bioRxiv [Preprint]. 2023 May 2:2023.05.02.539059. doi: 10.1101/2023.05.02.539059. bioRxiv. 2023. Update in: Cancer Res Commun. 2024 Aug 1;4(8):1908-1918. doi: 10.1158/2767-9764.CRC-23-0176 PMID: 37205503 Free PMC article. Updated. Preprint.
Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy.
Sikder K, Phillips E, Zhong Z, Wang N, Saunders J, Mothy D, Kossenkov A, Schneider T, Nichtova Z, Csordas G, Margulies KB, Choi JC. Sikder K, et al. Among authors: kossenkov a. bioRxiv [Preprint]. 2023 Jun 7:2023.02.14.528563. doi: 10.1101/2023.02.14.528563. bioRxiv. 2023. Update in: Sci Adv. 2024 May 10;10(19):eadh0798. doi: 10.1126/sciadv.adh0798 PMID: 36824975 Free PMC article. Updated. Preprint.
Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops.
Harada T, Kalfon J, Perez MW, Eagle K, Braes FD, Batley R, Heshmati Y, Ferrucio JX, Ewers J, Mehta S, Kossenkov A, Ellegast JM, Bowker A, Wickramasinghe J, Nabet B, Paralkar VR, Dharia NV, Stegmaier K, Orkin SH, Pimkin M. Harada T, et al. Among authors: kossenkov a. bioRxiv [Preprint]. 2023 Mar 15:2023.03.13.532438. doi: 10.1101/2023.03.13.532438. bioRxiv. 2023. PMID: 36993171 Free PMC article. Preprint.
Parkin activates innate immunity and promotes antitumor immune responses.
Perego M, Yeon M, Agarwal E, Milcarek AT, Bertolini I, Camisaschi C, Ghosh JC, Tang HY, Grandvaux N, Ruscetti M, Kossenkov AV, Preston-Alp S, Tempera I, Auslander N, Altieri DC. Perego M, et al. Among authors: kossenkov av. J Clin Invest. 2025 Jan 16;135(2):e190291. doi: 10.1172/JCI190291. J Clin Invest. 2025. PMID: 39817447 Free PMC article. No abstract available.
244 results