Wong PC - Search Results

1

Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia.

Baghel MS, Burns GD, Tsapatsis M, Mallika AP, Cruz ALF, Cao T, Chen XK, Rosa I, Marx SR, Ye Y, Sun S, Li T, Wong PC. Baghel MS, et al. Among authors: wong pc. bioRxiv [Preprint]. 2024 Jun 29:2024.06.26.600814. doi: 10.1101/2024.06.26.600814. bioRxiv. 2024. PMID: 38979270 Free PMC article. Preprint.

2

Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes.

Kim DW, Tu KJ, Wei A, Lau AJ, Gonzalez-Gil A, Cao T, Braunstein K, Ling JP, Troncoso JC, Wong PC, Blackshaw S, Schnaar RL, Li T. Kim DW, et al. Among authors: wong pc. Mol Neurodegener. 2022 Dec 17;17(1):83. doi: 10.1186/s13024-022-00589-x. Mol Neurodegener. 2022. PMID: 36536457 Free PMC article.

3

Elevated nuclear TDP-43 induces constitutive exon skipping.

Carmen-Orozco RP, Tsao W, Ye Y, Sinha IR, Chang K, Trinh V, Chung W, Bowden K, Troncoso JC, Blackshaw S, Hayes LR, Sun S, Wong PC, Ling JP. Carmen-Orozco RP, et al. Among authors: wong pc. bioRxiv [Preprint]. 2023 May 12:2023.05.11.540291. doi: 10.1101/2023.05.11.540291. bioRxiv. 2023. Update in: Mol Neurodegener. 2024 Jun 9;19(1):45. doi: 10.1186/s13024-024-00732-w PMID: 37215013 Free PMC article. Updated. Preprint.

4

Large-scale RNA-seq mining reveals ciclopirox triggers TDP-43 cryptic exons.

Sinha IR, Sandal PS, Burns GD, Mallika AP, Irwin KE, Cruz ALF, Wang V, Rodríguez JL, Wong PC, Ling JP. Sinha IR, et al. Among authors: wong pc. bioRxiv [Preprint]. 2024 Mar 30:2024.03.27.587011. doi: 10.1101/2024.03.27.587011. bioRxiv. 2024. PMID: 38585725 Free PMC article. Preprint.

5

[No title available]

[No authors listed] [No authors listed] PMID: 39751017

6

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.

Ma G, Li T, Price DL, Wong PC. Ma G, et al. Among authors: wong pc. J Neurosci. 2005 Jan 5;25(1):192-8. doi: 10.1523/JNEUROSCI.3814-04.2005. J Neurosci. 2005. PMID: 15634781 Free PMC article.

7

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.

Chiang PM, Fortna RR, Price DL, Li T, Wong PC. Chiang PM, et al. Among authors: wong pc. Neurobiol Aging. 2012 Feb;33(2):277-85. doi: 10.1016/j.neurobiolaging.2009.12.028. Epub 2010 Apr 10. Neurobiol Aging. 2012. PMID: 20382452 Free PMC article.

8

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model.

Li T, Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C, Wong PC. Li T, et al. Among authors: wong pc. Nat Commun. 2016 Jul 4;7:12082. doi: 10.1038/ncomms12082. Nat Commun. 2016. PMID: 27373369 Free PMC article.

9

D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI.

Chen L, Wei Z, Chan KW, Li Y, Suchal K, Bi S, Huang J, Xu X, Wong PC, Lu H, van Zijl PC, Li T, Xu J. Chen L, et al. Among authors: wong pc. J Cereb Blood Flow Metab. 2021 May;41(5):1013-1025. doi: 10.1177/0271678X20941264. Epub 2020 Jul 16. J Cereb Blood Flow Metab. 2021. PMID: 32669023 Free PMC article.

10

Early detection of Alzheimer's disease using creatine chemical exchange saturation transfer magnetic resonance imaging.

Chen L, van Zijl PCM, Wei Z, Lu H, Duan W, Wong PC, Li T, Xu J. Chen L, et al. Among authors: wong pc. Neuroimage. 2021 Aug 1;236:118071. doi: 10.1016/j.neuroimage.2021.118071. Epub 2021 Apr 18. Neuroimage. 2021. PMID: 33878375 Free PMC article.

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