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Page 1
Except for Robust Outliers, Rapamycin Increases Lesion Burden in a Murine Model of Cerebral Cavernous Malformations.
Alcazar-Felix RJ, Shenkar R, Benavides CR, Bindal A, Srinath A, Li Y, Kinkade S, Terranova T, DeBose-Scarlett E, Lightle R, DeBiasse D, Almazroue H, Cruz DV, Romanos S, Jhaveri A, Koskimäki J, Hage S, Bennett C, Girard R, Marchuk DA, Awad IA. Alcazar-Felix RJ, et al. Among authors: lightle r. Transl Stroke Res. 2024 Jul 9. doi: 10.1007/s12975-024-01270-9. Online ahead of print. Transl Stroke Res. 2024. PMID: 38980519
Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Koskimäki J, Zhang D, Lyne SB, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IA. Shenkar R, et al. Among authors: lightle r. Stroke. 2019 Mar;50(3):738-744. doi: 10.1161/STROKEAHA.118.024058. Stroke. 2019. PMID: 30744543 Free PMC article.
A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Koskimäki J, Girard R, Rosen K, Marchuk DA, Awad IA. McKerracher L, et al. Among authors: lightle r. Transl Stroke Res. 2020 Jun;11(3):365-376. doi: 10.1007/s12975-019-00725-8. Epub 2019 Aug 24. Transl Stroke Res. 2020. PMID: 31446620 Free PMC article.
Novel Murine Models of Cerebral Cavernous Malformations.
Detter MR, Shenkar R, Benavides CR, Neilson CA, Moore T, Lightle R, Hobson N, Shen L, Cao Y, Girard R, Zhang D, Griffin E, Gallione CJ, Awad IA, Marchuk DA. Detter MR, et al. Among authors: lightle r. Angiogenesis. 2020 Nov;23(4):651-666. doi: 10.1007/s10456-020-09736-8. Epub 2020 Jul 24. Angiogenesis. 2020. PMID: 32710309 Free PMC article.
Propranolol as therapy for cerebral cavernous malformations: a cautionary note.
Shenkar R, Moore T, Benavides C, Lightle R, Detter MR, Hobson N, Girard R, DeBiasse D, Patrucco M, Gallione C, Zabramski JM, Marchuk DA, Awad IA. Shenkar R, et al. Among authors: lightle r. J Transl Med. 2022 Apr 5;20(1):160. doi: 10.1186/s12967-022-03360-4. J Transl Med. 2022. PMID: 35382850 Free PMC article. No abstract available.
Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease.
Romanos SG, Srinath A, Li Y, Xie B, Chen C, Li Y, Moore T, Bi D, Sone JY, Lightle R, Hobson N, Zhang D, Koskimäki J, Shen L, McCurdy S, Lai CC, Stadnik A, Piedad K, Carrión-Penagos J, Shkoukani A, Snellings D, Shenkar R, Sulakhe D, Ji Y, Lopez-Ramirez MA, Kahn ML, Marchuk DA, Ginsberg MH, Girard R, Awad IA. Romanos SG, et al. Among authors: lightle r. Transl Stroke Res. 2023 Aug;14(4):513-529. doi: 10.1007/s12975-022-01050-3. Epub 2022 Jun 17. Transl Stroke Res. 2023. PMID: 35715588 Free PMC article.
mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice.
Li L, Ren AA, Gao S, Su YS, Yang J, Bockman J, Mericko-Ishizuka P, Griffin J, Shenkar R, Alcazar R, Moore T, Lightle R, DeBiasse D, Awad IA, Marchuk DA, Kahn ML, Burkhardt JK. Li L, et al. Among authors: lightle r. Stroke. 2023 Nov;54(11):2906-2917. doi: 10.1161/STROKEAHA.123.044108. Epub 2023 Sep 25. Stroke. 2023. PMID: 37746705 Free PMC article.
B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models.
Shi C, Shenkar R, Zeineddine HA, Girard R, Fam MD, Austin C, Moore T, Lightle R, Zhang L, Wu M, Cao Y, Gunel M, Louvi A, Rorrer A, Gallione C, Marchuk DA, Awad IA. Shi C, et al. Among authors: lightle r. J Neuroimmune Pharmacol. 2016 Jun;11(2):369-77. doi: 10.1007/s11481-016-9670-0. Epub 2016 Apr 16. J Neuroimmune Pharmacol. 2016. PMID: 27086141 Free PMC article.
Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
Girard R, Zeineddine HA, Orsbon C, Tan H, Moore T, Hobson N, Shenkar R, Lightle R, Shi C, Fam MD, Cao Y, Shen L, Neander AI, Rorrer A, Gallione C, Tang AT, Kahn ML, Marchuk DA, Luo ZX, Awad IA. Girard R, et al. Among authors: lightle r. J Neurosci Methods. 2016 Sep 15;271:14-24. doi: 10.1016/j.jneumeth.2016.06.021. Epub 2016 Jun 23. J Neurosci Methods. 2016. PMID: 27345427 Free PMC article.
39 results