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FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs.
Wasserman JS, Faezov B, Patel KR, Kurimchak AM, Palacio SM, Glass DJ, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL Jr, Graña X. Wasserman JS, et al. Among authors: kurimchak am. Nat Commun. 2024 Jul 10;15(1):5776. doi: 10.1038/s41467-024-50015-7. Nat Commun. 2024. PMID: 38982062 Free PMC article.
RAPID resistance to BET inhibitors is mediated by FGFR1 in glioblastoma.
Jermakowicz AM, Kurimchak AM, Johnson KJ, Bourgain-Guglielmetti F, Kaeppeli S, Affer M, Pradhyumnan H, Suter RK, Walters W, Cepero M, Duncan JS, Ayad NG. Jermakowicz AM, et al. Among authors: kurimchak am. Sci Rep. 2024 Apr 23;14(1):9284. doi: 10.1038/s41598-024-60031-8. Sci Rep. 2024. PMID: 38654040 Free PMC article.
Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints.
Cannon AC, Budagyan K, Uribe-Alvarez C, Kurimchak AM, Araiza-Olivera D, Cai KQ, Peri S, Zhou Y, Duncan JS, Chernoff J. Cannon AC, et al. Among authors: kurimchak am. bioRxiv [Preprint]. 2023 Jun 28:2023.06.27.546707. doi: 10.1101/2023.06.27.546707. bioRxiv. 2023. Update in: Oncogene. 2024 Mar;43(10):729-743. doi: 10.1038/s41388-024-02947-z PMID: 37425776 Free PMC article. Updated. Preprint.
Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target.
Kurimchak AM, Kumar V, Herrera-Montávez C, Johnson KJ, Srivastava N, Davarajan K, Peri S, Cai KQ, Mantia-Smaldone GM, Duncan JS. Kurimchak AM, et al. Mol Cell Proteomics. 2020 Dec;19(12):2068-2090. doi: 10.1074/mcp.RA120.002012. Epub 2020 Sep 29. Mol Cell Proteomics. 2020. PMID: 32994315 Free PMC article.
Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma.
Kurimchak AM, Herrera-Montávez C, Brown J, Johnson KJ, Sodi V, Srivastava N, Kumar V, Deihimi S, O'Brien S, Peri S, Mantia-Smaldone GM, Jain A, Winters RM, Cai KQ, Chernoff J, Connolly DC, Duncan JS. Kurimchak AM, et al. Sci Signal. 2020 Feb 18;13(619):eaax8238. doi: 10.1126/scisignal.aax8238. Sci Signal. 2020. PMID: 32071169 Free PMC article.
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