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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells.
Donnelly H, Ross E, Xiao Y, Hermantara R, Taqi AF, Doherty-Boyd WS, Cassels J, Tsimbouri PM, Dunn KM, Hay J, Cheng A, Meek RMD, Jain N, West C, Wheadon H, Michie AM, Peault B, West AG, Salmeron-Sanchez M, Dalby MJ. Donnelly H, et al. Among authors: michie am. Nat Commun. 2024 Jul 10;15(1):5791. doi: 10.1038/s41467-024-50054-0. Nat Commun. 2024. PMID: 38987295 Free PMC article.
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells.
Rattigan KM, Brabcova Z, Sarnello D, Zarou MM, Roy K, Kwan R, de Beauchamp L, Dawson A, Ianniciello A, Khalaf A, Kalkman ER, Scott MT, Dunn K, Sumpton D, Michie AM, Copland M, Tardito S, Gottlieb E, Vignir Helgason G. Rattigan KM, et al. Among authors: michie am. Nat Commun. 2023 Aug 17;14(1):4634. doi: 10.1038/s41467-023-40222-z. Nat Commun. 2023. PMID: 37591854 Free PMC article.
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LE, Kinstrie R, Guitart AV, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL. Sinclair A, et al. Among authors: michie am. Blood. 2016 Jul 21;128(3):371-83. doi: 10.1182/blood-2015-08-661785. Epub 2016 May 24. Blood. 2016. PMID: 27222476 Free PMC article.
67 results