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PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4.
Nguyen-Dien GT, Townsend B, Kulkarni PG, Kozul KL, Ooi SS, Eldershaw DN, Weeratunga S, Liu M, Jones MJ, Millard SS, Ng DC, Pagano M, Bonfim-Melo A, Schneider T, Komander D, Lazarou M, Collins BM, Pagan JK. Nguyen-Dien GT, et al. Among authors: lazarou m. EMBO Rep. 2024 Aug;25(8):3324-3347. doi: 10.1038/s44319-024-00181-y. Epub 2024 Jul 11. EMBO Rep. 2024. PMID: 38992176 Free PMC article.
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy.
Bernardini JP, Brouwer JM, Tan IK, Sandow JJ, Huang S, Stafford CA, Bankovacki A, Riffkin CD, Wardak AZ, Czabotar PE, Lazarou M, Dewson G. Bernardini JP, et al. Among authors: lazarou m. EMBO J. 2019 Jan 15;38(2):e99916. doi: 10.15252/embj.201899916. Epub 2018 Dec 20. EMBO J. 2019. PMID: 30573668 Free PMC article.
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors.
Nguyen-Dien GT, Kozul KL, Cui Y, Townsend B, Kulkarni PG, Ooi SS, Marzio A, Carrodus N, Zuryn S, Pagano M, Parton RG, Lazarou M, Millard SS, Taylor RW, Collins BM, Jones MJ, Pagan JK. Nguyen-Dien GT, et al. Among authors: lazarou m. EMBO J. 2023 Jul 3;42(13):e112767. doi: 10.15252/embj.2022112767. Epub 2023 May 10. EMBO J. 2023. PMID: 37161784 Free PMC article.
Mitochondrial degradation: Mitophagy and beyond.
Uoselis L, Nguyen TN, Lazarou M. Uoselis L, et al. Among authors: lazarou m. Mol Cell. 2023 Oct 5;83(19):3404-3420. doi: 10.1016/j.molcel.2023.08.021. Epub 2023 Sep 13. Mol Cell. 2023. PMID: 37708893 Free article. Review.
Interaction of PINK1 with nucleotides and kinetin.
Gan ZY, Callegari S, Nguyen TN, Kirk NS, Leis A, Lazarou M, Dewson G, Komander D. Gan ZY, et al. Among authors: lazarou m. Sci Adv. 2024 Jan 19;10(3):eadj7408. doi: 10.1126/sciadv.adj7408. Epub 2024 Jan 19. Sci Adv. 2024. PMID: 38241364 Free PMC article.
Parkin and mitophagy in cancer.
Bernardini JP, Lazarou M, Dewson G. Bernardini JP, et al. Among authors: lazarou m. Oncogene. 2017 Mar;36(10):1315-1327. doi: 10.1038/onc.2016.302. Epub 2016 Sep 5. Oncogene. 2017. PMID: 27593930 Review.
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy.
Kataura T, Otten EG, Rabanal-Ruiz Y, Adriaenssens E, Urselli F, Scialo F, Fan L, Smith GR, Dawson WM, Chen X, Yue WW, Bronowska AK, Carroll B, Martens S, Lazarou M, Korolchuk VI. Kataura T, et al. Among authors: lazarou m. EMBO J. 2023 Mar 1;42(5):e111372. doi: 10.15252/embj.2022111372. Epub 2022 Dec 14. EMBO J. 2023. PMID: 36514953 Free PMC article.
92 results