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CRISPR-Cas12a exhibits metal-dependent specificity switching.
Nguyen GT, Schelling MA, Raju A, Buscher KA, Sritharan A, Sashital DG. Nguyen GT, et al. Among authors: sashital dg. Nucleic Acids Res. 2024 Sep 9;52(16):9343-9359. doi: 10.1093/nar/gkae613. Nucleic Acids Res. 2024. PMID: 39019776 Free PMC article.
CRISPR interference and priming varies with individual spacer sequences.
Xue C, Seetharam AS, Musharova O, Severinov K, Brouns SJ, Severin AJ, Sashital DG. Xue C, et al. Among authors: sashital dg. Nucleic Acids Res. 2015 Dec 15;43(22):10831-47. doi: 10.1093/nar/gkv1259. Epub 2015 Nov 19. Nucleic Acids Res. 2015. PMID: 26586800 Free PMC article.
CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects.
Murugan K, Seetharam AS, Severin AJ, Sashital DG. Murugan K, et al. Among authors: sashital dg. J Biol Chem. 2020 Apr 24;295(17):5538-5553. doi: 10.1074/jbc.RA120.012933. Epub 2020 Mar 11. J Biol Chem. 2020. PMID: 32161115 Free PMC article.
An adaptable defense.
Schelling MA, Sashital DG. Schelling MA, et al. Among authors: sashital dg. Elife. 2020 Mar 30;9:e56122. doi: 10.7554/eLife.56122. Elife. 2020. PMID: 32223888 Free PMC article.
41 results