Zhou Z - Search Results

1

Design and optimization of piperidine-substituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles.

Sun Y, Zhou Z, Shi Z, Zhao F, Xie M, Zhuo Z, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Sun Y, et al. Among authors: zhou z. Acta Pharm Sin B. 2024 Jul;14(7):3110-3124. doi: 10.1016/j.apsb.2024.03.021. Epub 2024 Mar 27. Acta Pharm Sin B. 2024. PMID: 39027243 Free PMC article.

2

Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs.

Sun Y, Zhou Z, Feng D, Jing L, Zhao F, Wang Z, Zhang T, Lin H, Song H, De Clercq E, Pannecouque C, Zhan P, Liu X, Kang D. Sun Y, et al. Among authors: zhou z. J Med Chem. 2022 Dec 8;65(23):15608-15626. doi: 10.1021/acs.jmedchem.2c00576. Epub 2022 Nov 21. J Med Chem. 2022. PMID: 36411036

3

Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study.

Zhou Z, Meng B, An J, Zhao F, Sun Y, Zeng D, Wang W, Gao S, Xia Y, Dun C, De Clercq E, Pannecouque C, Zhan P, Kang D, Liu X. Zhou Z, et al. Int J Mol Sci. 2023 Jan 7;24(2):1215. doi: 10.3390/ijms24021215. Int J Mol Sci. 2023. PMID: 36674730 Free PMC article.

4

Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.

Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP. Shang P, et al. Among authors: zhou z. Cell. 2023 Nov 22;186(24):5347-5362.e24. doi: 10.1016/j.cell.2023.10.014. Epub 2023 Nov 13. Cell. 2023. PMID: 37963465 Free article.

5

In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket.

Sun Y, Feng D, Zhou Z, Zhang T, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Sun Y, et al. Among authors: zhou z. Bioorg Med Chem. 2023 Dec 15;96:117484. doi: 10.1016/j.bmc.2023.117484. Epub 2023 Sep 23. Bioorg Med Chem. 2023. PMID: 37976805

6

Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates.

Zhou Z, Zhang W, Zhao F, Sun Y, Wang N, Cheng J, Zhan P, Yang F, Sun JP, Liu X, Kang D. Zhou Z, et al. J Med Chem. 2024 Mar 14;67(5):4234-4249. doi: 10.1021/acs.jmedchem.4c00195. Epub 2024 Feb 28. J Med Chem. 2024. PMID: 38416116

7

Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs.

Sun Y, Zhou Z, Wang N, Zhao F, Liu Y, Xu X, Wang X, Gou Z, De Clercq E, Pannecouque C, Zhan P, Kang D, Liu X. Sun Y, et al. Among authors: zhou z. J Med Chem. 2024 Apr 25;67(8):6570-6584. doi: 10.1021/acs.jmedchem.4c00026. Epub 2024 Apr 13. J Med Chem. 2024. PMID: 38613773

8

Antiviral Drug Discovery.

Zhou Z, Liu X, Kang D. Zhou Z, et al. Int J Mol Sci. 2024 Jul 6;25(13):7413. doi: 10.3390/ijms25137413. Int J Mol Sci. 2024. PMID: 39000520 Free PMC article.

9

Discovery of 2,4,6-trisubstituted pyrimidine derivatives as novel potent HIV-1 NNRTIs by exploiting the tolerant region II of the NNIBP.

Zhou Z, Sun Y, Qin Y, Wang N, Zhao F, Wang Z, Clercq E, Pannecouque C, Zhan P, Kang D, Liu X. Zhou Z, et al. Eur J Med Chem. 2024 Nov 5;277:116708. doi: 10.1016/j.ejmech.2024.116708. Epub 2024 Jul 27. Eur J Med Chem. 2024. PMID: 39094273

10

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation.

Zhuo Z, Wang Z, Jing L, Zhang T, Ge A, Zhou Z, Liu Y, Li X, De Clercq E, Pannecouque C, Zhan P, Liu X, Kang D. Zhuo Z, et al. Among authors: zhou z. Int J Mol Sci. 2024 Aug 20;25(16):9028. doi: 10.3390/ijms25169028. Int J Mol Sci. 2024. PMID: 39201714 Free PMC article.

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