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Page 1
Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P. Zhang P, et al. Among authors: lusso p. Cell Rep. 2024 Aug 27;43(8):114518. doi: 10.1016/j.celrep.2024.114518. Epub 2024 Jul 18. Cell Rep. 2024. PMID: 39028623 Free PMC article.
Extremely potent monoclonal antibodies neutralize Omicron and other SARS-CoV-2 variants.
Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, Boyd LF, Nguyen H, Pomerenke A, Stephens T, Olia AS, De Giorgi V, Holbrook MR, Gross R, Postnikova E, Garza NL, Johnson RF, Margulies DH, Kwong PD, Alter HJ, Buchholz UJ, Lusso P, Farci P. Chen Z, et al. Among authors: lusso p. medRxiv [Preprint]. 2022 Jan 13:2022.01.12.22269023. doi: 10.1101/2022.01.12.22269023. medRxiv. 2022. Update in: Cell Rep. 2022 Nov 1;41(5):111528. doi: 10.1016/j.celrep.2022.111528 PMID: 35043120 Free PMC article. Updated. Preprint.
Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques.
Nouën CL, Nelson CE, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Yang L, Herbert R, Castens A, Moore IN, Wilder-Kofie T, Moore R, Walker A, Zhang P, Lusso P, Johnson RF, Garza NL, Via LE, Munir S, Barber D, Buchholz UJ. Nouën CL, et al. Among authors: lusso p. bioRxiv [Preprint]. 2022 May 23:2022.05.21.492923. doi: 10.1101/2022.05.21.492923. bioRxiv. 2022. Update in: Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2109744118. doi: 10.1073/pnas.2109744118 PMID: 35665011 Free PMC article. Updated. Preprint.
Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters.
Liu X, Park HS, Matsuoka Y, Santos C, Yang L, Luongo C, Moore IN, Johnson RF, Garza NL, Zhang P, Lusso P, Best SM, Buchholz UJ, Le Nouën C. Liu X, et al. Among authors: lusso p. bioRxiv [Preprint]. 2022 Dec 13:2022.12.12.520032. doi: 10.1101/2022.12.12.520032. bioRxiv. 2022. Update in: PLoS Pathog. 2023 Jun 23;19(6):e1011057. doi: 10.1371/journal.ppat.1011057 PMID: 36561185 Free PMC article. Updated. Preprint.
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
Sajadi MM, Abbasi A, Tehrani ZR, Siska C, Clark R, Chi W, Seaman MS, Mielke D, Wagh K, Liu Q, Jumpa T, Ketchem RR, Nguyen DN, Tolbert WD, Pierce BG, Atkinson B, Deming D, Sprague M, Asakawa A, Ferrer D, Dunn Y, Calvillo S, Yin R, Guest JD, Korber B, Mayer BT, Sato AH, Ouyang X, Foulke S, Habibzadeh P, Karimi M, Aslanabadi A, Hojabri M, Saadat S, Zareidoodeji R, Kędzior M, Pozharski E, Heredia A, Montefiori D, Ferrari G, Pazgier M, Lewis GK, Jardine JG, Lusso P, DeVico A. Sajadi MM, et al. Among authors: lusso p. bioRxiv [Preprint]. 2024 Oct 17:2024.10.14.618178. doi: 10.1101/2024.10.14.618178. bioRxiv. 2024. PMID: 39464103 Free PMC article. Preprint.
Increased neutralization potency and breadth elicited by a SARS-CoV-2 mRNA vaccine forming virus-like particles.
Zhang P, Falcone S, Tsybovsky Y, Singh M, Gopan V, Miao H, Seo Y, Rogers D, Renzi I, Lai YT, Narayanan E, Stewart-Jones G, Himansu S, Carfi A, Fauci AS, Lusso P. Zhang P, et al. Among authors: lusso p. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2305896120. doi: 10.1073/pnas.2305896120. Epub 2023 Jul 10. Proc Natl Acad Sci U S A. 2023. PMID: 37428933 Free PMC article.
Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters.
Liu X, Park HS, Matsuoka Y, Santos C, Yang L, Luongo C, Moore IN, Johnson RF, Garza NL, Zhang P, Lusso P, Best SM, Buchholz UJ, Le Nouën C. Liu X, et al. Among authors: lusso p. PLoS Pathog. 2023 Jun 23;19(6):e1011057. doi: 10.1371/journal.ppat.1011057. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37352333 Free PMC article.
Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain.
Kwon YD, Pegu A, Yang ES, Zhang B, Bender MF, Asokan M, Liu Q, McKee K, Lin BC, Liu T, Louder MK, Rawi R, Reveiz M, Schaub AJ, Shen CH, Doria-Rose NA, Lusso P, Mascola JR, Kwong PD. Kwon YD, et al. Among authors: lusso p. MAbs. 2023 Jan-Dec;15(1):2223350. doi: 10.1080/19420862.2023.2223350. MAbs. 2023. PMID: 37345226 Free PMC article.
223 results