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Phase 1 dose escalation study of the MDM2 inhibitor milademetan as monotherapy and in combination with azacitidine in patients with myeloid malignancies.
DiNardo CD, Olin R, Wang ES, Skikne B, Rosenthal J, Kumar P, Sumi H, Hizukuri Y, Hong Y, Patel P, Seki T, Duan T, Lesegretain A, Andreeff M. DiNardo CD, et al. Among authors: hizukuri y. Cancer Med. 2024 Jul;13(14):e70028. doi: 10.1002/cam4.70028. Cancer Med. 2024. PMID: 39030997 Free PMC article. Clinical Trial.
Valemetostat monotherapy in patients with relapsed or refractory non-Hodgkin lymphoma: a first-in-human, multicentre, open-label, single-arm, phase 1 study.
Maruyama D, Jacobsen E, Porcu P, Allen P, Ishitsuka K, Kusumoto S, Narita T, Tobinai K, Foss F, Tsukasaki K, Feldman T, Imaizumi Y, Izutsu K, Morishima S, Yamauchi N, Yuda J, Brammer JE, Kawamata T, Ruan J, Nosaka K, Utsunomiya A, Wang J, Zain J, Kakurai Y, Yamauchi H, Hizukuri Y, Biserna N, Tachibana M, Inoue A, Horwitz SM. Maruyama D, et al. Among authors: hizukuri y. Lancet Oncol. 2024 Dec;25(12):1589-1601. doi: 10.1016/S1470-2045(24)00502-3. Epub 2024 Oct 29. Lancet Oncol. 2024. PMID: 39486432 Clinical Trial.
Mechanisms of action and resistance in histone methylation-targeted therapy.
Yamagishi M, Kuze Y, Kobayashi S, Nakashima M, Morishima S, Kawamata T, Makiyama J, Suzuki K, Seki M, Abe K, Imamura K, Watanabe E, Tsuchiya K, Yasumatsu I, Takayama G, Hizukuri Y, Ito K, Taira Y, Nannya Y, Tojo A, Watanabe T, Tsutsumi S, Suzuki Y, Uchimaru K. Yamagishi M, et al. Among authors: hizukuri y. Nature. 2024 Mar;627(8002):221-228. doi: 10.1038/s41586-024-07103-x. Epub 2024 Feb 21. Nature. 2024. PMID: 38383791 Free PMC article.
The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA.
Watanabe A, Koyano F, Imai K, Hizukuri Y, Ogiwara S, Ito T, Miyamoto J, Shibuya C, Kimura M, Toriumi K, Motono C, Arai M, Tanaka K, Akiyama Y, Yamano K, Matsuda N. Watanabe A, et al. Among authors: hizukuri y. J Biol Chem. 2024 Jul;300(7):107476. doi: 10.1016/j.jbc.2024.107476. Epub 2024 Jun 13. J Biol Chem. 2024. PMID: 38879013 Free PMC article.
Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.
Imaizumi Y, Takanuki K, Miyake T, Takemoto M, Hirata K, Hirose M, Oi R, Kobayashi T, Miyoshi K, Aruga R, Yokoyama T, Katagiri S, Matsuura H, Iwasaki K, Kato T, Kaneko MK, Kato Y, Tajiri M, Akashi S, Nureki O, Hizukuri Y, Akiyama Y, Nogi T. Imaizumi Y, et al. Among authors: hizukuri y. Sci Adv. 2022 Aug 26;8(34):eabp9011. doi: 10.1126/sciadv.abp9011. Epub 2022 Aug 24. Sci Adv. 2022. PMID: 36001659 Free PMC article.
Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion.
Tamura-Sakaguchi R, Aruga R, Hirose M, Ekimoto T, Miyake T, Hizukuri Y, Oi R, Kaneko MK, Kato Y, Akiyama Y, Ikeguchi M, Iwasaki K, Nogi T. Tamura-Sakaguchi R, et al. Among authors: hizukuri y. Acta Crystallogr D Struct Biol. 2021 May 1;77(Pt 5):645-662. doi: 10.1107/S2059798321002527. Epub 2021 Apr 19. Acta Crystallogr D Struct Biol. 2021. PMID: 33950020 Free PMC article.
33 results