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MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α.
Kovaleva V, Yu LY, Ivanova L, Shpironok O, Nam J, Eesmaa A, Kumpula EP, Sakson S, Toots U, Ustav M, Huiskonen JT, Voutilainen MH, Lindholm P, Karelson M, Saarma M. Kovaleva V, et al. Among authors: saarma m. Cell Rep. 2023 Feb 28;42(2):112066. doi: 10.1016/j.celrep.2023.112066. Epub 2023 Feb 3. Cell Rep. 2023. PMID: 36739529 Free article.
Viral and nonviral approaches.
Airavaara M, Saarma M. Airavaara M, et al. Among authors: saarma m. Handb Clin Neurol. 2024;205:83-97. doi: 10.1016/B978-0-323-90120-8.00008-3. Handb Clin Neurol. 2024. PMID: 39341664 Review.
Brain Targeting Nanomedicines: Pitfalls and Promise.
Kakinen A, Jiang Y, Davis TP, Teesalu T, Saarma M. Kakinen A, et al. Among authors: saarma m. Int J Nanomedicine. 2024 May 27;19:4857-4875. doi: 10.2147/IJN.S454553. eCollection 2024. Int J Nanomedicine. 2024. PMID: 38828195 Free PMC article. Review.
CDNF and ER stress: Pharmacology and therapeutic possibilities.
Lõhelaid H, Saarma M, Airavaara M. Lõhelaid H, et al. Among authors: saarma m. Pharmacol Ther. 2024 Feb;254:108594. doi: 10.1016/j.pharmthera.2024.108594. Epub 2024 Jan 28. Pharmacol Ther. 2024. PMID: 38290651 Free article. Review.
Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial.
Huttunen HJ, Booms S, Sjögren M, Kerstens V, Johansson J, Holmnäs R, Koskinen J, Kulesskaya N, Fazio P, Woolley M, Brady A, Williams J, Johnson D, Dailami N, Gray W, Levo R, Saarma M, Halldin C, Marjamaa J, Resendiz-Nieves J, Grubor I, Lind G, Eerola-Rautio J, Mertsalmi T, Andréasson M, Paul G, Rinne J, Kivisaari R, Bjartmarz H, Almqvist P, Varrone A, Scheperjans F, Widner H, Svenningsson P. Huttunen HJ, et al. Among authors: saarma m. Mov Disord. 2023 Jul;38(7):1209-1222. doi: 10.1002/mds.29426. Epub 2023 May 22. Mov Disord. 2023. PMID: 37212361 Clinical Trial.
305 results