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An atlas of genetic effects on cellular composition of the tumor microenvironment.
Cai Y, Lu Z, Chen C, Zhu Y, Chen Z, Wu Z, Peng J, Zhu X, Liu Z, Li B, Zhang M, Huang J, Li Y, Liu Y, Ma Q, He C, Chen S, Tian W, Fan L, Ning C, Geng H, Xu B, Li H, Zhu X, Fang J, Wang X, Zhang S, Jin M, Huang C, Yang X, Tian J, Miao X. Cai Y, et al. Among authors: zhu x, zhu y. Nat Immunol. 2024 Oct;25(10):1959-1975. doi: 10.1038/s41590-024-01945-3. Epub 2024 Sep 2. Nat Immunol. 2024. PMID: 39223350
Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers.
Cai YM, Lu ZQ, Li B, Huang JY, Zhang M, Chen C, Fan LY, Ma QY, He CY, Chen SN, Jiang Y, Li YM, Ning CB, Zhang FW, Wang WZ, Liu YZ, Zhang H, Jin M, Wang XY, Han JX, Xiong Z, Cai M, Huang CQ, Yang XJ, Zhu X, Zhu Y, Miao XP, Zhang SK, Wei YC, Tian JB. Cai YM, et al. Among authors: zhu x, zhu y. Mil Med Res. 2024 Jun 11;11(1):36. doi: 10.1186/s40779-024-00539-2. Mil Med Res. 2024. PMID: 38863031 Free PMC article.
HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer-promoter interaction.
Lu Z, Fan L, Zhang F, Huang C, Cai Y, Chen C, Li G, Zhang M, Huang J, Ning C, Li Y, Wang W, Geng H, Liu Y, Chen S, Li H, Yang S, Zhang H, Tian W, Ye T, Liu J, Yang X, Xu B, Zhu Y, Zhong R, Li H, Tian J, Li B, Miao X. Lu Z, et al. Among authors: zhu y. Arch Toxicol. 2023 Jul;97(7):2015-2028. doi: 10.1007/s00204-023-03494-4. Epub 2023 May 28. Arch Toxicol. 2023. PMID: 37245169
A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis.
Zou D, Cai Y, Jin M, Zhang M, Liu Y, Chen S, Yang S, Zhang H, Zhu X, Huang C, Zhu Y, Miao X, Wei Y, Yang X, Tian J. Zou D, et al. Among authors: zhu x, zhu y. Chin Med J (Engl). 2024 Feb 20;137(4):431-440. doi: 10.1097/CM9.0000000000002845. Epub 2023 Sep 8. Chin Med J (Engl). 2024. PMID: 37690994 Free PMC article.
Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.
Zhu Y, Wei Y, Zhang R, Dong X, Shen S, Zhao Y, Bai J, Albanes D, Caporaso NE, Landi MT, Zhu B, Chanock SJ, Gu F, Lam S, Tsao MS, Shepherd FA, Tardon A, Fernández-Somoano A, Fernandez-Tardon G, Chen C, Barnett MJ, Doherty J, Bojesen SE, Johansson M, Brennan P, McKay JD, Carreras-Torres R, Muley T, Risch A, Wichmann HE, Bickeboeller H, Rosenberger A, Rennert G, Saliba W, Arnold SM, Field JK, Davies MPA, Marcus MW, Wu X, Ye Y, Le Marchand L, Wilkens LR, Melander O, Manjer J, Brunnström H, Hung RJ, Liu G, Brhane Y, Kachuri L, Andrew AS, Duell EJ, Kiemeney LA, van der Heijden EH, Haugen A, Zienolddiny S, Skaug V, Grankvist K, Johansson M, Woll PJ, Cox A, Taylor F, Teare DM, Lazarus P, Schabath MB, Aldrich MC, Houlston RS, McLaughlin J, Stevens VL, Shen H, Hu Z, Dai J, Amos CI, Han Y, Zhu D, Goodman GE, Chen F, Christiani DC. Zhu Y, et al. Among authors: zhu b, zhu d. Cancer Epidemiol Biomarkers Prev. 2019 May;28(5):935-942. doi: 10.1158/1055-9965.EPI-18-0356. Epub 2019 Jan 30. Cancer Epidemiol Biomarkers Prev. 2019. PMID: 30700444 Free PMC article.
A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians.
Zhang R, Shen S, Wei Y, Zhu Y, Li Y, Chen J, Guan J, Pan Z, Wang Y, Zhu M, Xie J, Xiao X, Zhu D, Li Y, Albanes D, Landi MT, Caporaso NE, Lam S, Tardon A, Chen C, Bojesen SE, Johansson M, Risch A, Bickeböller H, Wichmann HE, Rennert G, Arnold S, Brennan P, McKay JD, Field JK, Shete SS, Le Marchand L, Liu G, Andrew AS, Kiemeney LA, Zienolddiny-Narui S, Behndig A, Johansson M, Cox A, Lazarus P, Schabath MB, Aldrich MC, Dai J, Ma H, Zhao Y, Hu Z, Hung RJ, Amos CI, Shen H, Chen F, Christiani DC. Zhang R, et al. Among authors: zhu d, zhu y, zhu m. J Thorac Oncol. 2022 Aug;17(8):974-990. doi: 10.1016/j.jtho.2022.04.011. Epub 2022 Apr 30. J Thorac Oncol. 2022. PMID: 35500836 Free PMC article.
Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients.
Chen C, Wei Y, Wei L, Chen J, Chen X, Dong X, He J, Lin L, Zhu Y, Huang H, You D, Lai L, Shen S, Duan W, Su L, Shafer A, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Wang R, Staaf J, Helland Å, Esteller M, Zhang R, Chen F, Christiani DC. Chen C, et al. Among authors: zhu y. Aging (Albany NY). 2020 Jun 8;12(11):10642-10662. doi: 10.18632/aging.103284. Epub 2020 Jun 8. Aging (Albany NY). 2020. PMID: 32511103 Free PMC article.
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