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Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry.
Kwok CHT, Harding EK, Burma NE, Markovic T, Massaly N, van den Hoogen NJ, Stokes-Heck S, Gambeta E, Komarek K, Yoon HJ, Navis KE, McAllister BB, Canet-Pons J, Fan C, Dalgarno R, Gorobets E, Papatzimas JW, Zhang Z, Kohro Y, Anderson CL, Thompson RJ, Derksen DJ, Morón JA, Zamponi GW, Trang T. Kwok CHT, et al. Among authors: trang t. Nat Commun. 2024 Jul 24;15(1):6264. doi: 10.1038/s41467-024-50657-7. Nat Commun. 2024. PMID: 39048565 Free PMC article.
Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents.
Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankara JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, De Koninck Y, Trang T. Burma NE, et al. Among authors: trang t. Nat Med. 2017 Mar;23(3):355-360. doi: 10.1038/nm.4281. Epub 2017 Jan 30. Nat Med. 2017. PMID: 28134928 Free article.
Therapies and mechanisms of opioid withdrawal.
Burma NE, Kwok CH, Trang T. Burma NE, et al. Among authors: trang t. Pain Manag. 2017 Nov;7(6):455-459. doi: 10.2217/pmt-2017-0028. Epub 2017 Nov 10. Pain Manag. 2017. PMID: 29125396 No abstract available.
Microglial pannexin-1 channel activation is a spinal determinant of joint pain.
Mousseau M, Burma NE, Lee KY, Leduc-Pessah H, Kwok CHT, Reid AR, O'Brien M, Sagalajev B, Stratton JA, Patrick N, Stemkowski PL, Biernaskie J, Zamponi GW, Salo P, McDougall JJ, Prescott SA, Matyas JR, Trang T. Mousseau M, et al. Among authors: trang t. Sci Adv. 2018 Aug 8;4(8):eaas9846. doi: 10.1126/sciadv.aas9846. eCollection 2018 Aug. Sci Adv. 2018. PMID: 30101191 Free PMC article.
Targeting Pannexin-1 Channels: Addressing the 'Gap' in Chronic Pain.
McAllister BB, Stokes-Heck S, Harding EK, van den Hoogen NJ, Trang T. McAllister BB, et al. Among authors: trang t. CNS Drugs. 2024 Feb;38(2):77-91. doi: 10.1007/s40263-024-01061-8. Epub 2024 Feb 14. CNS Drugs. 2024. PMID: 38353876 Review.
158 results