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Page 1
Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells.
Louisse J, Fragki S, Rijkers D, Janssen A, van Dijk B, Leenders L, Staats M, Bokkers B, Zeilmaker M, Piersma A, Luijten M, Hoogenboom R, Peijnenburg A. Louisse J, et al. Among authors: fragki s. Arch Toxicol. 2023 Apr;97(4):1113-1131. doi: 10.1007/s00204-023-03450-2. Epub 2023 Mar 3. Arch Toxicol. 2023. PMID: 36864359 Free PMC article.
Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.
Najjar A, Punt A, Wambaugh J, Paini A, Ellison C, Fragki S, Bianchi E, Zhang F, Westerhout J, Mueller D, Li H, Shi Q, Gant TW, Botham P, Bars R, Piersma A, van Ravenzwaay B, Kramer NI. Najjar A, et al. Among authors: fragki s. Arch Toxicol. 2022 Dec;96(12):3407-3419. doi: 10.1007/s00204-022-03356-5. Epub 2022 Sep 5. Arch Toxicol. 2022. PMID: 36063173 Free PMC article.
Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
Fragki S, Dirven H, Fletcher T, Grasl-Kraupp B, Bjerve Gützkow K, Hoogenboom R, Kersten S, Lindeman B, Louisse J, Peijnenburg A, Piersma AH, Princen HMG, Uhl M, Westerhout J, Zeilmaker MJ, Luijten M. Fragki S, et al. Crit Rev Toxicol. 2021 Feb;51(2):141-164. doi: 10.1080/10408444.2021.1888073. Epub 2021 Apr 15. Crit Rev Toxicol. 2021. PMID: 33853480 Free article. Review.