Shah DP - Search Results

1

Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy.

A M Subbaiah M, Mandal U, Patankar V, Bhaskaran S, Nutakki R, Rami B, Shah DP, Mahammad S, Murphy BJ, Huang C, Robl JA, Washburn WN. A M Subbaiah M, et al. Among authors: shah dp. Eur J Med Chem. 2024 Oct 5;276:116686. doi: 10.1016/j.ejmech.2024.116686. Epub 2024 Jul 20. Eur J Med Chem. 2024. PMID: 39053192

2

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.

Xu L, Hartz RA, Beno BR, Ghosh K, Shukla JK, Kumar A, Patel D, Kalidindi N, Lemos N, Gautam SS, Kumar A, Ellsworth BA, Shah D, Sale H, Cheng D, Regueiro-Ren A. Xu L, et al. J Med Chem. 2021 May 27;64(10):6634-6655. doi: 10.1021/acs.jmedchem.0c02001. Epub 2021 May 14. J Med Chem. 2021. PMID: 33988358

3

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

Liu C, Jalagam PR, Feng J, Wang W, Raja T, Sura MR, Manepalli RKVLP, Aliphedi BR, Medavarapu S, Nair SK, Muthalagu V, Natesan R, Gupta A, Beno B, Panda M, Ghosh K, Shukla JK, Sale H, Haldar P, Kalidindi N, Shah D, Patel D, Mathur A, Ellsworth BA, Cheng D, Regueiro-Ren A. Liu C, et al. J Med Chem. 2022 Aug 25;65(16):11084-11099. doi: 10.1021/acs.jmedchem.2c00517. Epub 2022 Aug 15. J Med Chem. 2022. PMID: 35969688

4

Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: Early liability assessment during lead optimization.

Saxena A, Shah D, Padmanabhan S, Gautam SS, Chowan GS, Mandlekar S, Desikan S. Saxena A, et al. Eur J Pharm Sci. 2015 Aug 30;76:173-80. doi: 10.1016/j.ejps.2015.05.006. Epub 2015 May 8. Eur J Pharm Sci. 2015. PMID: 25960252

5

Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions.

Chu J, Panfen E, Wang L, Marino A, Chen XQ, Fancher RM, Landage R, Patil O, Desai SD, Shah D, Xue Y, Sinz M, Shen H. Chu J, et al. Pharm Res. 2023 Nov;40(11):2567-2584. doi: 10.1007/s11095-023-03563-4. Epub 2023 Jul 31. Pharm Res. 2023. PMID: 37523014

6

A systematic evaluation of solubility enhancing excipients to enable the generation of permeability data for poorly soluble compounds in Caco-2 model.

Shah D, Paruchury S, Matta M, Chowan G, Subramanian M, Saxena A, Soars MG, Herbst J, Haskell R, Marathe P, Mandlekar S. Shah D, et al. Drug Metab Lett. 2014;8(2):109-18. doi: 10.2174/1872312808666141127113055. Drug Metab Lett. 2014. PMID: 25429513

7

Absolute quantification of imipramine and its metabolites in vivo utilizing calibrators from radiolabeled in vitro incubations.

Bhutani P, Shah D, Varkhede N, Mandlekar S, Chacko S, Subramanian M. Bhutani P, et al. Bioanalysis. 2016 Feb;8(4):297-309. doi: 10.4155/bio.15.259. Epub 2016 Feb 5. Bioanalysis. 2016. PMID: 26847656

8

2024 Update of the RECOVER-Adult Long COVID Research Index.

Geng LN, Erlandson KM, Hornig M, Letts R, Selvaggi C, Ashktorab H, Atieh O, Bartram L, Brim H, Brosnahan SB, Brown J, Castro M, Charney A, Chen P, Deeks SG, Erdmann N, Flaherman VJ, Ghamloush MA, Goepfert P, Goldman JD, Han JE, Hess R, Hirshberg E, Hoover SE, Katz SD, Kelly JD, Klein JD, Krishnan JA, Lee-Iannotti J, Levitan EB, Marconi VC, Metz TD, Modes ME, Nikolich JŽ, Novak RM, Ofotokun I, Okumura MJ, Parthasarathy S, Patterson TF, Peluso MJ, Poppas A, Quintero Cardona O, Scott J, Shellito J, Sherif ZA, Singer NG, Taylor BS, Thaweethai T, Verduzco-Gutierrez M, Wisnivesky J, McComsey GA, Horwitz LI, Foulkes AS; RECOVER Consortium. Geng LN, et al. JAMA. 2024 Dec 18. doi: 10.1001/jama.2024.24184. Online ahead of print. JAMA. 2024. PMID: 39693079

9

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-b]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis.

Foutz MA, Krinos EL, Beretta M, Hargett SR, Shrestha R, Murray JH, Duerre E, Salamoun JM, McCarter K, Shah DP, Hoehn KL, Santos WL. Foutz MA, et al. Among authors: shah dp. J Med Chem. 2024 Dec 12;67(23):21486-21504. doi: 10.1021/acs.jmedchem.4c02366. Epub 2024 Nov 30. J Med Chem. 2024. PMID: 39614818 Free PMC article.

10

Complete inhibition of liver acetyl-CoA carboxylase activity is required to exacerbate liver tumorigenesis in mice treated with diethylnitrosamine.

Shrestha R, Vancuylenburg CS, Beretta M, Zhou M, Shah DP, Olzomer EM, Richards SL, Hoehn KL, Byrne FL. Shrestha R, et al. Among authors: shah dp. Cancer Metab. 2024 Nov 13;12(1):34. doi: 10.1186/s40170-024-00363-1. Cancer Metab. 2024. PMID: 39538356 Free PMC article.

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