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A single mutation G454A in the P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy.
Djoko Tagne CS, Kouamo MFM, Tchouakui M, Muhammad A, Mugenzi LJL, Tatchou-Nebangwa NMT, Thiomela RF, Gadji M, Wondji MJ, Hearn J, Desire MH, Ibrahim SS, Wondji CS. Djoko Tagne CS, et al. Among authors: thiomela rf. Genetics. 2024 Nov 7:iyae181. doi: 10.1093/genetics/iyae181. Online ahead of print. Genetics. 2024. PMID: 39509710
Substrate promiscuity of key resistance P450s confers clothianidin resistance while increasing chlorfenapyr potency in malaria vectors.
Tchouakui M, Ibrahim SS, Mangoua MK, Thiomela RF, Assatse T, Ngongang-Yipmo SL, Muhammad A, Mugenzi LJM, Menze BD, Mzilahowa T, Wondji CS. Tchouakui M, et al. Among authors: thiomela rf. Cell Rep. 2024 Aug 27;43(8):114566. doi: 10.1016/j.celrep.2024.114566. Epub 2024 Jul 31. Cell Rep. 2024. PMID: 39088320 Free PMC article.