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Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis.
Xu Y, Korayem A, Cruz-Solbes AS, Chandel N, Sakata T, Mazurek R, Mavropoulos SA, Kariya T, Aikawa T, Yamada KP, D'Escamard V, V'Gangula B, Baker AH, Ma L, Björkegren JLM, Fuster V, Boehm M, Fish KM, Tadros R, Ishikawa K, Kovacic JC. Xu Y, et al. Among authors: chandel n. Cardiovasc Res. 2024 Nov 25;120(14):1768-1779. doi: 10.1093/cvr/cvae157. Cardiovasc Res. 2024. PMID: 39056563 Free PMC article.
Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype.
Lecce L, Xu Y, V'Gangula B, Chandel N, Pothula V, Caudrillier A, Santini MP, d'Escamard V, Ceholski DK, Gorski PA, Ma L, Koplev S, Bjørklund MM, Björkegren JL, Boehm M, Bentzon JF, Fuster V, Kim HW, Weintraub NL, Baker AH, Bernstein E, Kovacic JC. Lecce L, et al. Among authors: chandel n. J Clin Invest. 2021 Aug 2;131(15):e131178. doi: 10.1172/JCI131178. J Clin Invest. 2021. PMID: 34338228 Free PMC article.
The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1.
Ma L, Bryce NS, Turner AW, Di Narzo AF, Rahman K, Xu Y, Ermel R, Sukhavasi K, d'Escamard V, Chandel N, V'Gangula B, Wolhuter K, Kadian-Dodov D, Franzen O, Ruusalepp A, Hao K, Miller CL, Björkegren JLM, Kovacic JC. Ma L, et al. Among authors: chandel n. PLoS Genet. 2022 Jun 17;18(6):e1010261. doi: 10.1371/journal.pgen.1010261. eCollection 2022 Jun. PLoS Genet. 2022. PMID: 35714152 Free PMC article.
Integrative Prioritization of Causal Genes for Coronary Artery Disease.
Hao K, Ermel R, Sukhavasi K, Cheng H, Ma L, Li L, Amadori L, Koplev S, Franzén O, d'Escamard V, Chandel N, Wolhuter K, Bryce NS, Venkata VRM, Miller CL, Ruusalepp A, Schunkert H, Björkegren JLM, Kovacic JC. Hao K, et al. Among authors: chandel n. Circ Genom Precis Med. 2022 Feb;15(1):e003365. doi: 10.1161/CIRCGEN.121.003365. Epub 2021 Dec 28. Circ Genom Precis Med. 2022. PMID: 34961328 Free PMC article.
Metformin targets mitochondrial complex I to lower blood glucose levels.
Reczek CR, Chakrabarty RP, D'Alessandro KB, Sebo ZL, Grant RA, Gao P, Budinger GR, Chandel NS. Reczek CR, et al. Among authors: chandel ns. Sci Adv. 2024 Dec 20;10(51):eads5466. doi: 10.1126/sciadv.ads5466. Epub 2024 Dec 18. Sci Adv. 2024. PMID: 39693440 Free PMC article.
IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma.
Karakousi T, Cristaldi V, Lopes de Oliveira ML, Medeiros Geraldo LH, González-Robles TJ, da Silva G, Breazeale AP, Encarnacion-Rosado J, Pozniak J, Kimmelman AC, Ruggles KV, Chris Marine J, Chandel NS, Lund AW. Karakousi T, et al. Among authors: chandel ns. bioRxiv [Preprint]. 2024 Dec 5:2024.12.02.626426. doi: 10.1101/2024.12.02.626426. bioRxiv. 2024. PMID: 39677662 Free PMC article. Preprint.
Post-ischemic inactivation of HIF Prolyl Hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis.
Tiwari R, Sharma R, Rajendran G, Borkowski GS, An SY, Schonfeld M, O'Sullivan J, Schipma MJ, Zhou Y, Courbon G, Thomson BR, David V, Quaggin SE, Thorp EB, Chandel NS, Kapitsinou PP. Tiwari R, et al. Among authors: chandel ns. J Clin Invest. 2024 Nov 26:e176207. doi: 10.1172/JCI176207. Online ahead of print. J Clin Invest. 2024. PMID: 39621585 Free article.
382 results